FIGHT VIRUSES, DISEASES, AND CANCERS.

Critical Immune Defense®

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Your cat's immune system is the key to its health

Critical Immune Defense is a safe, all-natural immune booster that can add years to the life of your cat. Made in the USA.

✔︎ Boosts immune system

✔︎ Reduces inflammation

✔︎ Promotes normal cell growth

✔︎ Protects against toxins in food, water & environment

✔︎ Supports long-term health in cats and dogs

“My cat is 15 and has feline herpes. In the past, I have given her lysine with very little results. Since taking Critical Immune Defense I have seen a steady improvement. Hardly any eye discharge and her nose isn’t wet anymore. No difficulty breathing at all. My son said, “What took you so long to find this stuff?” I also give it to my 3-year-old dog, she’s healthy but …..just in case. They both eat it and have no problem eating all their food.” - Lisa

"Mushrooms (cancer tumor), Tumeric (anti-inflammatory), and Milk Thistle (rejuvenate the liver). I'm giving it to all my cats and double the dose for this one with an enlarged abdomen that the vets can't figure out. Her belly was getting so big and painful, like gas; it was like a bloated cow. The vets didn't think anything was in there... just a mystery. I figured the liver could be in distress, so regardless if it's fluid in there or full of tumors in there, this Critical Immune Defense powder is working.

Today she jumped down from a shelf, her belly is not nearly as round or hard, and I saw her belly jiggle when she reached the floor. This picture is of Rose. I really believe Critical Immune Defense is saving her life. ” - Donna

“I have a rescue and keep 8 senior and special needs cats. I give them this for cats, and it has proven to extend the lives of those who were in danger of losing their lives from cancer, renal failure, and, frankly, only God knows what else! I am grateful for this formula being available for seniors we adore and aren’t really ready to cross the 🌈 yet❣️👍😻 This was Foxy Loxy. He had been failing(14 yrs old), but as he received Pet Wellness Support, he recovered his enjoyment of life, and I could love him for 2 more years❣️ I have other kitties' who had experienced similar recoveries through Pet Wellness. Thank you again!”❣️- Mat

"The vet said he had a mass on his shoulder. We could either amputate or bring him home for palliative care only. He’s 10, so we brought him home. After antibiotics, he seemed to be better but still very lethargic. Since this happened last week, his health has gotten so much better. The mass has either diminished in size or is gone. He’s more alert and is almost 100% weight-bearing. Here he is last week. He seems so much more comfortable now. His name is Pineapple (named by my grandson).” - Elizabeth

“My sweet Tux got sick and vets could not figure out why. As he lay on my lap with a high fever I ordered this product and prayed. It came quickly and I immediately gave him some, luckily by this time he was a little better and eating some. Within three days he was almost himself again. In one week he was back to himself.

This stuff is amazing! God gave us everything to heal and nourish our body and this product is His gift. I now give it to his brother and our pups. Our oldest pup had a lump at the base of his tail, it is now 3/4 gone! HIGHLY RECOMMEND and I tell everyone!” - Cory

Where have you seen us

Your pet's immune system is the key to its health! Here's why:

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it. Your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive!

Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

Your pet's immune system is the key to its health! Here's why:

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it. Your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive!

Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

50%

CANCER RATES ARE SKYROCKETING

THE DOCTORS AGREE

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

More cats and dogs are being diagnosed with cancer than ever before. 

“Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

Turkey Tail Mushroom

This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

✔︎ Delivers significant amounts of tumor-fighting Polysaccharopeptides (PSPs)

✔︎ Approved by the United States Food & Drug Administration for use in treating prostate and breast cancer in humans

✔︎ Proven to delay the growth of cancerous tumors in pets and improve their survival rate

Reishi Mushroom

This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

✔︎ Contains beta-glucans that increase the immune system’s T-cell levels

✔︎ Lowers inflammatory responses caused by stress, poor diet, and other environmental factors

✔︎ Contains ganoderic acids that have been shown to lower cholesterol levels and blood pressure

Shiitake Mushroom

According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

✔︎ Contains all 8 essential amino acids as well as linoleic acid, an essential fatty acid

✔︎ Used in Japan to treat heart disease, hepatitis, high blood pressure, and infectious diseases

Maitake Mushroom

Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

✔︎ Contains beta-1, 6 glucan polysaccharide components that stimulate the immune system and reduce abnormal cell growth

✔︎ Used in Asia to help minimize the toxic effects of radiation and chemotherapy treatment

White Turmeric Root Extract

Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and liver damage.

Our proprietary extract is six times more bioavailable than standard turmeric root, which means it’s more effectively absorbed into your pet’s body and they need less of it to get the same effect. It’s also colorless and milder tasting, making it easier to handle -- and tastier for your pet! No more turmeric stains!

Your pet’s immune system is one of the most critical parts of its health.

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Your pet’s immune system is one of the most critical parts of its health.

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Not only is it easy to use (just sprinkle it over your pet’s food) -- your pet will love the taste!

Approx. 70 Scoops Per Container

3 bottles every 90 days.

Save $30. Free shipping. Change or cancel at anytime.

Made in the USA to the highest quality standards.

VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved pet’s health.

Frequently Asked Questions

Still have questions?

Talk to us on Facebook Messenger

Or give us a call at 888-212-8400 Mon-Fri 9:00 to 5:00 PST

Returns | 30-Day Money Back | Ingredients

average rating 4.7 out of 5
Based on 1035 reviews
  • 5 Stars
    860 Reviews
  • 4 Stars
    104 Reviews
  • 3 Stars
    50 Reviews
  • 2 Stars
    7 Reviews
  • 1 Star
    14 Reviews
93% of reviewers would recommend this product to a friend
Effectiveness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
1035 Reviews
Reviewed by Michelle W.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Labrador
Pet Problem(s)
  • Limp
  • Tumor
  • Inflammation
  • Joint Pain
Will Consume Product
Enjoyed
Pet Happiness
Tail Wagging

My older labs lumps dissolved

We have seen a huge change in the size of the lumps on our 12yr old lab since using this product for about 6months

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Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Was this helpful?

Pet Wellness Direct

Hi Michelle! Thank you for sharing the wonderful progress your 12-year-old Lab has made with Critical Immune Defense. It's fantastic to hear that the lumps have significantly reduced in size over the past six months. Your Lab looks beautiful in the photos and video, and seeing such positive results is heartening. Your dedication to their health and well-being is truly inspiring. 🐾💖

Reviewed by Susan W.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Basset Hound
Pet Problem(s)
  • Bad Breath
  • Low Energy
  • Joint Pain
Will Consume Product
Nibbled
Pet Happiness
Tail Wagging

Amazing Transformation

I ordered the Critical Immune Defense for my Bagel girl Marmalade. She lost her older Basset Hound brother last year who was 16 and was starting to show signs of depression since she was now the only dog. She also turned 13 (now she is a teenager) in April so I thought the product would help protect her health. For a couple of months there was not a big change but by month three I could see a difference. She was perkier, eating better and back to her usual mischievous self.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Was this helpful?

Pet Wellness Direct

Hi Susan! Thank you for sharing Marmalade's amazing transformation! We're so glad our Critical Immune Defense has helped your 13-year-old Basset Hound regain her perkiness and appetite. Marmalade looks absolutely adorable in the photo, and it's wonderful to see her back to her mischievous self. Your dedication to her well-being is truly inspiring. 🐾💖

Reviewed by LouAnn C.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
3 - 5 Years
Dog Breed
Boston Terrier
Pet Problem(s)
  • Tumor
Will Consume Product
Devoured
Pet Happiness
Tail Wagging

Histiocytoma

My Boston terrier at 5 yrs of age developed a large tumor on his neck, where his collar sat. While not malignant, it had to be surgically removed. He has also had severe hives reactions with his annual vaccines in the past. One year after his surgery for histiocytoma, he began to develop multiple growths on his head and back which looked similar to his original growth. The vet advised that this was most likely the same type of growth as he appears to be very reactive. Following a steroid shot, I began to use Critical Immune Defense and the multiple growths disappeared in a few weeks. I have kept him on it since, with no further problems. I also give it to my nearly 15 yr. old Sheltie, who has had awful dental problems and horrible breath. That seems to be improving some as well. I am very satisfied with your product and intend to keep using it.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Was this helpful?

Pet Wellness Direct

Thank you, LouAnn, for sharing your pup's journey with us! We're thrilled to hear how Critical Immune Defense swiftly resolved his histiocytoma growths, and seeing him so happy and healthy in the photo you shared warms our hearts. It's also great to hear about your senior Sheltie's dental health improvements. We're here to support you and your furry family members always!

Reviewed by Terry H.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
7 - 10 Years
Dog Breed
Labrador
Pet Problem(s)
  • Low Energy
  • Inflammation
  • Hip Pain
  • Joint Pain
  • Limp

Critical immune Defense

Both our dogs are big an they just didn't seem really excited anymore. One is a 10yr old lab an other is a mix of saint Benard he's 8yrs old. Once we started giving them this immune defense they are playing more now.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Terry, Thank you for sharing your experience! It's wonderful to hear that your 10-year-old Lab and 8-year-old Saint Bernard mix are more energetic and playful. The pictures of your dogs are adorable! We're so glad Critical Immune Defense has helped. 🐾❤️

Reviewed by Jane F.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
5 - 7 Years
Pet Problem(s)
  • Joint Pain
  • Inflammation

Tight cervicals

My little chi/doxi mix has back issues, especially in his neck. I put him on Critical Immune Defense about a year ago and his bouts with neck pain have diminished greatly! All 3 dogs and 8 cats are on this product. It’s palatable and easy to feed. Highly recommend!!

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Jane, Thank you for sharing your positive experience with Critical Immune Defense! It's wonderful to hear your Chi/Doxi mix's neck pain has greatly diminished. Your dedication to all your pets is inspiring. The pictures of your pets are adorable! We're glad our product has made a difference. 🐾❤️