Critical Immune Defense™️

For Dogs & Cats
Order Now

A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎ Boosts immune system

✔︎ Reduces inflammation

✔︎ Promotes normal cell growth

✔︎ Protects against toxins in food, water & environment

✔︎ Supports long-term health in dogs and cats

Critical Immune Defense™️

FIGHT VIRUSES, DISEASES, AND CANCERS.

Your pet's immune system is the key to its health

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it. Your dog and cat lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive!

Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a dog’s immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

Your pet's immune system is the key to its health

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it. Your dog and cat lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive!

Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a dog’s immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

50%

CANCER RATES ARE SKYROCKETING

More dogs and cats are being diagnosed with cancer than ever before. 

According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

“One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

According to Dr. Edwards, another way to protect your pets is with all-natural health supplements

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

“Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

More dogs and cats are being diagnosed with cancer than ever before. 

According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

“One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

According to Dr. Edwards, another way to protect your pets is with all-natural health supplements

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

“Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

The doctors agree.

Dr. Frank Markland

Professor of Biochemistry and Molecular Medicine at the University of Southern California Keck School of Medicine

Dr. Shawn Messonnier

Veterinary Medicine and author of "The Natural Vet's Guide to Preventing and Treating Cancer in Dogs"

Dr. Jennifer Edwards

Ponemah Veterinary Hospital

Introducing

Critical Immune Defense™️

For Dogs & Cats

Strengthens the immune system

Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

Protects against diseases

Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

Promotes normal cell growth

Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

Works with prescription medications

Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

Can extend your pet's life

Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

Backed by science

Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

4 Medicinal Mushrooms That Can Help Protect Your Pet from Disease

This all-natural supplement is a unique blend of four powerful mushrooms, plus concentrated white turmeric extract and a potent vitamin cocktail that boosts “good cell” development and strengthens your pet’s immune system.

These mushrooms were carefully selected for this product and are extremely high in antioxidants and other vital biologically active compounds that have been proven to strengthen the immune system and promote longevity.

Turkey Tail Mushroom

This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

✔︎ Delivers significant amounts of tumor-fighting Polysaccharopeptides (PSPs)

✔︎ Approved by the United States Food & Drug Administration for use in treating prostate and breast cancer in humans

✔︎ Proven to delay the growth of cancerous tumors in dogs and improve their survival rate

Reishi Mushroom

This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

✔︎ Contains beta-glucans that increase the immune system’s T-cell levels

✔︎ Lowers inflammatory responses caused by stress, poor diet, and other environmental factors

✔︎ Contains ganoderic acids that have been shown to lower cholesterol levels and blood pressure

Shiitake Mushroom

According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

✔︎ Contains all 8 essential amino acids as well as linoleic acid, an essential fatty acid

✔︎ Used in Japan to treat heart disease, hepatitis, high blood pressure, and infectious diseases

Maitake Mushroom

Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

✔︎ Contains beta-1, 6 glucan polysaccharide components that stimulate the immune system and reduce abnormal cell growth

✔︎ Used in Asia to help minimize the toxic effects of radiation and chemotherapy treatment

White Turmeric Root Extract

Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and liver damage.

Our proprietary extract is six times more bioavailable than standard turmeric root, which means it’s more effectively absorbed into your pet’s body and they need less of it to get the same effect. It’s also colorless and milder tasting, making it easier to handle -- and tastier for your pet! No more turmeric stains!

Your pet’s immune system is one of the most critical parts of its health.

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Your pet’s immune system is one of the most critical parts of its health.

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Customer Testimonials

“The Difference In His Health And Energy Is Amazing!”

Debbie

I’ve been giving this to my 4-year-old boxer for almost one year. He has a large fatty tumor right behind his shoulder. I finally noticed it’s half its size now. Not to mention how beautiful his coat is. He is very healthy. Now that I’m seeing changes, I will always give him CID.

Cynthia

My girl (Great Dane) was diagnosed with cancer last May...we found out about this product and started using it last July...she just had her 9th birthday in January...you wouldn't even know she has cancer...we love this product and will keep using it ❤❤❤🐾❤ I will keep you updated🙂here is a picture of my Zoey ❤

Kathryn

The vet said to watch it; if it increases in size, he would need surgery. I got 3 bottles of this and am finishing the 2nd one tonight on our 3 dogs. His growth is starting to get smaller. Ordered 3 more bottles today! Thank you for this product!

Tamara

I believe CID has given me more time with my Yorkie, Moseley -- several months beyond what our vet thought. We would not have had the precious time otherwise. He was also 15 years old. Thankful that we tried it.

Kelly

We are giving this to our 10-year-old yellow lab.  About 5 months ago, she could barely go up and down the steps, but today, there are no issues. So many times, you buy a product online, it doesn’t work, and you just move on, thinking that you just wasted money again. Not this time; this was 100% a good choice. Thank you!

Lina

Here’s my Puggys 2nd bottle. In my 1st bottle in only a week, I noticed he was more playful & energetic. I was surprised because every day now, he wakes me up wanting to play. Before the end of 1 bottle, his soft lump flattened. We are still working on diminishing his other soft lump under the breast bone. So far, I’m impressed. I believe. I also noticed his ear allergies are gone. He usually has an ear infection. Looks like his ears have no yeast that he used to scratch. I will continue & look forward to order again. More power.

Heidi

My little guy here has a fatty tumor on his side, and sadly, the vet took X-rays and found a tumor on his heart. I started him on your product a couple weeks ago, and he has gotten more energy is more alert, and can get in and out the doggie doors by himself again. I will definitely keep him on your product, and I am hoping it may shrink the tumor on his heart, either way the vet was ready to send him over the rainbow bridge I said no I was going to try your product! He is a changed dog, and he used to cough often, and he doesn’t as much!❤️thank you for giving me more time with him!

Not only is it easy to use (just sprinkle it over your pet’s food) -- your pet will love the taste!

Approx. 70 Scoops Per Container

The All-Natural Solution. Trusted By Veterinarians.

Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

✔︎ No artificial colors

✔︎ No artificial flavors

✔︎ Wheat-free

Try it RISK FREE

One bottle per month.
Save 15% and get free shipping.
Change or cancel at anytime.

30 Day Money Back Guarantee.

Most popular

3 bottles per month.
Save 15% and get free shipping.
Change or cancel at anytime.

30 Day Money Back Guarantee.

Super Saver

6 bottles per month.
Save 15% and get free shipping.
Change or cancel at anytime.

30 Day Money Back Guarantee.

Made in the USA to the highest quality standards.

VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved pet’s health.

Frequently Asked Questions

Still have questions?

Talk to us on Facebook Messenger

Or give us a call at 888-212-8400 Mon-Fri 9:00 to 5:00 PST

Returns | 30-Day Money Back | Ingredients

average rating 4.7 out of 5
Based on 892 reviews
  • 5 Stars
    737 Reviews
  • 4 Stars
    93 Reviews
  • 3 Stars
    43 Reviews
  • 2 Stars
    7 Reviews
  • 1 Star
    12 Reviews
93% of reviewers would recommend this product to a friend
Effectiveness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Customer photos and videos
892 Reviews
Reviewed by Maureen J.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
7 - 10 Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Overweight
  • Tumor
  • Joint Pain
  • Cancer

Great product

My dog loves it and her lumps have almost disappeared. So happy with it.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Maureen, thank you for sharing your pup's wonderful progress with us! We're thrilled to hear about her improved health and how much she's enjoying the Critical Immune Defense. 🐾 🐶💕

Reviewed by Jamie C.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Jack Russell
Pet Problem(s)
  • Tumor
  • Cancer
  • Low Energy
  • Stress

My dog has prostate cancer

My little boy has had a rapidly growing prostate tumor since October 2023. We have been on and off heavy duty antibiotics for reoccurring urinary tract infections. He has been on a cancer, patient medication to help control the growth of the tumor as well as pain. We started this product a month ago, and since starting this product, he has gone back to being puppy like. His appetite has greatly increased. Honestly better than it has been in years. I thought we would have to say goodbye very soon, and gave this product a try as a last ditch effort. It has honestly given him his life back. He was very depressed, now he is happy and energetic. I hope that it slows the tumor down enough to give us many more months, if not years.

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Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Jamie, thank you for sharing your Jack Russell's journey with prostate cancer. We're so happy to hear how Critical Immune Defense has brought back his puppy-like energy and hearty appetite, giving him a new lease on life. The transformation is truly inspiring, and we're honored to have played a part in his well-being. Here's to many more joyful moments together! 🐾

Reviewed by Sheila N.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Tumor
  • Bad Breath

.

Our 12 year old puggle has been on this for more than 3 months . He runs around effortlessly. And his lymps and bumps have shrunk. Tho they have not gone away. At the least they have not gotten any bigger. Will continue the product.

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Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Sheila, thank you for sharing your positive experience with Critical Immune Defense! It's wonderful to hear about your 12-year-old puggle's improved energy and health progress. We're committed to supporting him on his journey to wellness. Keep up the great work! 🐾

Reviewed by Julie M.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Chihuahua
Pet Problem(s)
  • Tumor
  • Cancer

This is a miracle. Thank God and thank Pet Wellness!

My 10 yr old chihuahua has a mast cyst tumor on her back leg. Vet found it late last year. They wanted to cut her leg off. No way. I started giving her the critical immune defense in December. The tumor has reduced in size- it’s 1/3 the size it was. In two months’ time. Before and after pictures below. This stuff is a Godsend.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Julie, Thank you for sharing such an amazing progress story about your chihuahua! It's heartening to see the positive impact of Pet Wellness Critical Immune Defense on reducing her mast cyst tumor. 🙌 Your dedication to her health is truly inspiring. Wishing your sweet pup continued well-being and happiness!

Reviewed by Kelly R.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Collie
Pet Problem(s)
  • Inflammation
  • Bad Breath

Great results acheived

I have had great results w/my CH. Smooth Collie bitch Evie, GCHB Cyndella's ICandy. Evie will be 11 in May and was in pretty good health, but was diagnosed w/Urinary Incontinence last year. She has been taking prescribed medicine DES, but wanted to find something so I could lower the dose. I have been able to cut her back to almost just 1 a week. She does get blood work every 6 months, but I really feel this has helped and also increased her energy level. Thanks for your product discovered on Facebook.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 0 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Kelly, Thank you for sharing Evie's amazing progress with us! It's heartening to hear how our product has positively impacted her health, especially in managing her urinary incontinence. 🐾 Your trust means the world to us, and we're here to support Evie's well-being every step of the way!