Critical Immune Defense®

For Dogs & Cats
Order Now

A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎ Boosts immune system

✔︎ Reduces inflammation

✔︎ Promotes normal cell growth

✔︎ Protects against toxins in food, water & environment

✔︎ Supports long-term health in dogs and cats

Critical Immune Defense™️

FIGHT VIRUSES, DISEASES, AND CANCERS.

Your pet's immune system is the key to its health

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it. Your dog and cat lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive!

Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a dog’s immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

Your pet's immune system is the key to its health

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it. Your dog and cat lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive!

Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a dog’s immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

50%

CANCER RATES ARE SKYROCKETING

More dogs and cats are being diagnosed with cancer than ever before. 

According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

“One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

According to Dr. Edwards, another way to protect your pets is with all-natural health supplements

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

“Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

More dogs and cats are being diagnosed with cancer than ever before. 

According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

“One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

According to Dr. Edwards, another way to protect your pets is with all-natural health supplements

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

“Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

The doctors agree.

Dr. Frank Markland

Professor of Biochemistry and Molecular Medicine at the University of Southern California Keck School of Medicine

Dr. Shawn Messonnier

Veterinary Medicine and author of "The Natural Vet's Guide to Preventing and Treating Cancer in Dogs"

Dr. Jennifer Edwards

Ponemah Veterinary Hospital

Introducing

Critical Immune Defense™️

For Dogs & Cats

Strengthens the immune system

Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

Protects against diseases

Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

Promotes normal cell growth

Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

Works with prescription medications

Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

Can extend your pet's life

Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

Backed by science

Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

4 Medicinal Mushrooms That Can Help Protect Your Pet from Disease

This all-natural supplement is a unique blend of four powerful mushrooms, plus concentrated white turmeric extract and a potent vitamin cocktail that boosts “good cell” development and strengthens your pet’s immune system.

These mushrooms were carefully selected for this product and are extremely high in antioxidants and other vital biologically active compounds that have been proven to strengthen the immune system and promote longevity.

Turkey Tail Mushroom

This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

✔︎ Delivers significant amounts of tumor-fighting Polysaccharopeptides (PSPs)

✔︎ Approved by the United States Food & Drug Administration for use in treating prostate and breast cancer in humans

✔︎ Proven to delay the growth of cancerous tumors in dogs and improve their survival rate

Reishi Mushroom

This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

✔︎ Contains beta-glucans that increase the immune system’s T-cell levels

✔︎ Lowers inflammatory responses caused by stress, poor diet, and other environmental factors

✔︎ Contains ganoderic acids that have been shown to lower cholesterol levels and blood pressure

Shiitake Mushroom

According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

✔︎ Contains all 8 essential amino acids as well as linoleic acid, an essential fatty acid

✔︎ Used in Japan to treat heart disease, hepatitis, high blood pressure, and infectious diseases

Maitake Mushroom

Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

✔︎ Contains beta-1, 6 glucan polysaccharide components that stimulate the immune system and reduce abnormal cell growth

✔︎ Used in Asia to help minimize the toxic effects of radiation and chemotherapy treatment

White Turmeric Root Extract

Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and liver damage.

Our proprietary extract is six times more bioavailable than standard turmeric root, which means it’s more effectively absorbed into your pet’s body and they need less of it to get the same effect. It’s also colorless and milder tasting, making it easier to handle -- and tastier for your pet! No more turmeric stains!

Your pet’s immune system is one of the most critical parts of its health.

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Your pet’s immune system is one of the most critical parts of its health.

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Customer Testimonials

“The Difference In His Health And Energy Is Amazing!”

Debbie

I’ve been giving this to my 4-year-old boxer for almost one year. He has a large fatty tumor right behind his shoulder. I finally noticed it’s half its size now. Not to mention how beautiful his coat is. He is very healthy. Now that I’m seeing changes, I will always give him CID.

Cynthia

My girl (Great Dane) was diagnosed with cancer last May...we found out about this product and started using it last July...she just had her 9th birthday in January...you wouldn't even know she has cancer...we love this product and will keep using it ❤❤❤🐾❤ I will keep you updated🙂here is a picture of my Zoey ❤

Kathryn

The vet said to watch it; if it increases in size, he would need surgery. I got 3 bottles of this and am finishing the 2nd one tonight on our 3 dogs. His growth is starting to get smaller. Ordered 3 more bottles today! Thank you for this product!

Tamara

I believe CID has given me more time with my Yorkie, Moseley -- several months beyond what our vet thought. We would not have had the precious time otherwise. He was also 15 years old. Thankful that we tried it.

Kelly

We are giving this to our 10-year-old yellow lab.  About 5 months ago, she could barely go up and down the steps, but today, there are no issues. So many times, you buy a product online, it doesn’t work, and you just move on, thinking that you just wasted money again. Not this time; this was 100% a good choice. Thank you!

Lina

Here’s my Puggys 2nd bottle. In my 1st bottle in only a week, I noticed he was more playful & energetic. I was surprised because every day now, he wakes me up wanting to play. Before the end of 1 bottle, his soft lump flattened. We are still working on diminishing his other soft lump under the breast bone. So far, I’m impressed. I believe. I also noticed his ear allergies are gone. He usually has an ear infection. Looks like his ears have no yeast that he used to scratch. I will continue & look forward to order again. More power.

Heidi

My little guy here has a fatty tumor on his side, and sadly, the vet took X-rays and found a tumor on his heart. I started him on your product a couple weeks ago, and he has gotten more energy is more alert, and can get in and out the doggie doors by himself again. I will definitely keep him on your product, and I am hoping it may shrink the tumor on his heart, either way the vet was ready to send him over the rainbow bridge I said no I was going to try your product! He is a changed dog, and he used to cough often, and he doesn’t as much!❤️thank you for giving me more time with him!

Not only is it easy to use (just sprinkle it over your pet’s food) -- your pet will love the taste!

Approx. 70 Scoops Per Container

The All-Natural Solution. Trusted By Veterinarians.

Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

✔︎ No artificial colors

✔︎ No artificial flavors

✔︎ Wheat-free

Try it RISK FREE

One bottle per month.
Save 15% and get free shipping.
Change or cancel at anytime.

30 Day Money Back Guarantee.

Most popular

3 bottles per month.
Save 15% and get free shipping.
Change or cancel at anytime.

30 Day Money Back Guarantee.

Super Saver

6 bottles per month.
Save 15% and get free shipping.
Change or cancel at anytime.

30 Day Money Back Guarantee.

Made in the USA to the highest quality standards.

VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved pet’s health.

Frequently Asked Questions

Still have questions?

Talk to us on Facebook Messenger

Or give us a call at 888-212-8400 Mon-Fri 9:00 to 5:00 PST

Returns | 30-Day Money Back | Ingredients

average rating 4.7 out of 5
Based on 957 reviews
  • 5 Stars
    793 Reviews
  • 4 Stars
    98 Reviews
  • 3 Stars
    47 Reviews
  • 2 Stars
    7 Reviews
  • 1 Star
    12 Reviews
93% of reviewers would recommend this product to a friend
Effectiveness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
957 Reviews
Reviewed by Kathleen A.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
5 - 7 Years
Dog Breed
Pitbull Terrier
Pet Problem(s)
  • Tumor
  • Stress
  • Inflammation

Critical Immune Defense

Penny Lane has suffered from mast cell tumors and fatty cysts. Since using the critical immune defense she has not experienced any new tumos, lumps or bumps. Her energy is good and her health is great. I will continue to use this product everyday.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Kathleen! 🐾 We're thrilled to hear about Penny Lane's amazing progress with our Critical Immune Defense supplement! It's wonderful that she hasn't experienced any new tumors or lumps since starting the regimen. The picture you shared of her is adorable! 🌟🐾

Reviewed by Chuck D.
Verified Buyer
Review posted
I recommend this product
Rated 4 out of 5
Pet Age
10+ Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Cancer
  • Joint Pain

Not a 30 day amount at 2 scoops twice daily for a 65 lb dog

Having almost finished my third bottle , I can see some improvement in my dogs urine color.

He has bladder cancer and before starting with the CID he would have some blood in his urine at times.

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Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Chuck, 🐾 Thank you for sharing your pup's progress with Critical Immune Defense. Keep up the amazing care, and know that we're here to support you both. Here's to more positive improvements and cherished moments together! 🌟🐾

Reviewed by Cande J.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Welsh Corgi
Pet Problem(s)
  • Inflammation
  • Bad Breath

Seen a difference

Noticed an improvement in bad breath and activity

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Effectiveness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 0 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Cande, Thank you for sharing your pup's positive progress with Critical Immune Defense. It's fantastic to hear about the improvement in bad breath and activity levels. 🐾 Here's to continued improvement and many more joyful moments together! 🌟

Reviewed by Nancy L.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
7 - 10 Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Cancer

Jake

Our boy Jake has cutaneous hemangiosarcoma. He has had two surgeries to remove a surface tumor which grew back. We have decided no more surgeries, and giving him Critcal Inmune Defense along with other healthy supplements. This seems to be keeping the small surface tumor in check. He is a very happy boy.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Nancy, Thank you for sharing Jake's health journey with us. We're glad to hear that Critical Immune Defense is helping him stay happy and healthy and we're here to support you both every step of the way. 🌟

Reviewed by Joanne G.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
5 - 7 Years
Dog Breed
Chihuahua
Pet Problem(s)
  • Cancer
  • Overweight
  • Tumor

Elvis is doing well

In January Elvis was diagnosed with Lymphoma and given 2-3 months . I was told he also had a large mass in his abdomen. The first picture is in January and the second picture is March. He has been on Critical Immune Defense for 3 months and I've noticed a significant change. He is doing well with lots of energy. I attribute this to the supplement -Critical Immune Defense , a change of diet, and the Dr. said Prednisone is helping. I will keep him on this supplement!

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?

Pet Wellness Direct

Hi Joanne, Your update on Elvis's health journey is truly heartening! 🐾 Seeing his remarkable transformation from January to March fills us with joy and hope. Elvis looks happy and energetic in the pictures you shared, a testament to his resilience and your unwavering support. Keep up the fantastic work, and give Elvis an extra cuddle from us! 🌟