FIGHT VIRUSES, DISEASES, AND CANCERS.

Critical Immune Defense for Dogs

Rated 4.8 out of 5
Based on 1582 reviews
Size: Small | 70 Scoops
Free shipping on all US mainland orders

There simply isn't another product of this quality and strength available on the market, with THOUSANDS of testimonials about the results!

Critical Immune Defense is a safe, all-natural immune booster that can add years to the life of your dog.
Made in the USA with certified organic mushrooms.

Just sprinkle a small amount of powder on your dog's food. It tastes great, even for the most finicky of pets!

✔︎ Boosts immune system

✔︎ Reduces inflammation

✔︎ Promotes normal cell growth

✔︎ Protects against toxins in food, water & environment

✔︎ Supports long-term health in dogs and cats

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"I've lost two golden retrievers to cancer, so I've been doing a ton of research since I got my newest puppy. I want to give him the best chance of living a long and healthy life and Critical Immune Defense is a key part to that equation. He likes it and I believe in being proactive! So glad I found this company!"

- Audrey (Verified Customer)

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"30 days ago I went to a cancer specialist who told me that my dog’s prognosis was not very good and he would eventually get lumps and tumors all over his body. I left very depressed.
I found your product online by a miracle, and I started giving it to him. I don't know what it’s doing, but all older cancer tumors are gone and it seems to have eliminated the new tumors as well. I've been giving the VetSmart product twice a day for approximately 30 days. I'm just so grateful and so thankful that it works so well. He is looking really, really good. Thank you so much! I need to order more soon.”

- Paul (Verified Customer)

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Featured on

Your pet's immune system is the key to its health! Here's why:

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers. In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it: your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive! Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

Your pet's immune system is the key to its health! Here's why:

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers. In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it: your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive! Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

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"My female pitbull was diagnosed with lymphoma back in 2020. We did chemo for 2 years. During this time, I found the product and started using it on all my dogs, even healthy ones.

We are now in almost 4 years later, and my girl Haven has been in remission for almost 2 years. I only give the product in the dinner feedings. I believe it saved her."

- Diane (Verified Customer)

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"Sienna is 13 years old and is on two of your products. She been on this for several weeks and noticing a difference in enjoying the stairs again. Thank you for both! ❤️❤️❤️
Critical Immune Defense, has made a huge difference with a lump on her shoulder! Sienna is taking two of your products Critical Immune Defense, for a lump on her shoulder which has shrunk, to half its size after finishing first container, working on
Papilloma virus warts and skin tags...have two containers to go.
Sienna started having issues using the steps. I started her on your Hip+Joint product and within 10 days, no longer any issues. Sienna will be 14 this year. Loving these products 🙏🏻🤞🏻 in time Critical Immune Defense will help with the virus...."

- Gloria (Verified Customer)

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52%

CANCER RATES ARE SKYROCKETING

THE DOCTORS AGREE

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

More dogs and cats are being diagnosed with cancer than ever before. 

“Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

Organic Turkey Tail Mushrooms

This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

✔︎ Delivers significant amounts of tumor-fighting Polysaccharopeptides (PSPs)

✔︎ Approved by the United States Food & Drug Administration for use in treating prostate and breast cancer in humans

✔︎ Proven to delay the growth of cancerous tumors in pets and improve their survival rate

Organic Reishi Mushrooms

This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

✔︎ Contains beta-glucans that increase the immune system’s T-cell levels

✔︎ Lowers inflammatory responses caused by stress, poor diet, and other environmental factors

✔︎ Contains ganoderic acids that have been shown to lower cholesterol levels and blood pressure

Organic Shiitake Mushrooms

According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

✔︎ Contains all 8 essential amino acids as well as linoleic acid, an essential fatty acid

✔︎ Used in Japan to treat heart disease, hepatitis, high blood pressure, and infectious diseases

Organic Maitake Mushrooms

Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

✔︎ Contains beta-1, 6 glucan polysaccharide components that stimulate the immune system and reduce abnormal cell growth

✔︎ Used in Asia to help minimize the toxic effects of radiation and chemotherapy treatment

White Turmeric Root Extract

Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and liver damage.

Our proprietary extract is six times more bioavailable than standard turmeric root, which means it’s more effectively absorbed into your pet’s body and they need less of it to get the same effect. It’s also colorless and milder tasting, making it easier to handle -- and tastier for your pet! No more turmeric stains!

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"My dog is now 21 years old and this has helped so much. She is on her 3rd bottle, things were grown on face they are much smaller. She used to go to bathroom on herself, now she gets out of bed to go. She is close to 22, she eats at least 2 big meals a day! I know each day is a blessing with her! She is a Boston terrier and Rat terrier. this has helped tremendously! Thank you for giving her new time! Her eyes have also gotten much brighter too!"

- Gina (Verified Customer)

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Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

70 Scoops in a small bottle
210 scoops in a large bottle
10% Additional Saving

⭐️⭐️⭐️⭐️⭐️

"This product has been a blessing for our Ellie. Diagnosed with mast cell cancer given 1 year to live that was almost 4 yrs ago. She will be 12 in a few months we started her on this when she was 8 yr old. Still doing fantastic plays and acts like a puppy. Love this product.”

- Edie (Verified Customer)

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The All-Natural Solution. Trusted By Veterinarians.

Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

✔︎ Certified organic mushrooms

✔︎ No artificial colors or flavors

✔︎ Wheat-free

Made in the USA to the highest quality standards.

VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs. Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved pet’s health.

Frequently Asked Questions

Still have questions?

Talk to us on Facebook Messenger

Or give us a call at 888-212-8400 Mon-Fri 9:00 to 5:00 PST

Returns | 30-Day Money Back | Ingredients

average rating 4.8 out of 5
Based on 1582 reviews
  • 5 Stars
    1342 Reviews
  • 4 Stars
    170 Reviews
  • 3 Stars
    61 Reviews
  • 2 Stars
    2 Reviews
  • 1 Star
    7 Reviews
96% of reviewers would recommend this product to a friend
Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
1582 Reviews
Reviewed by Betty S.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Yorkshire terrier
Pet Problem(s)
  • Joint Pain
  • Inflammation
  • Tumor
Will Consume Product
Devoured
Pet Happiness
Tail Wagging

Healthy Yorkies

I have 2 senior yorkies and one of them is prone to developing little pinkish button sized lumps. She currently has one on her leg, one on her neck and one on her leg. Since I have been giving them Critical Immune Defense, the lumps have reduced in size by about half.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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Pet Wellness Direct

Thank you for sharing your Yorkies’ experience! 💛 We’re so glad to hear you’ve noticed positive changes since adding Critical Immune Defense to their daily routine. 🐶✨ We truly appreciate your trust in supporting your senior pups’ wellness!

Reviewed by terry a.
Verified Buyer
Review posted
I recommend this product
Rated 4 out of 5
Pet Age
10+ Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Joint Pain
  • Low Energy
  • Inflammation
  • Hip Pain
  • Limp
Will Consume Product
Devoured
Pet Happiness
Tail Wagging

beard progress..

bear has 1 lump on the right side of his neck that was full of liquid so i would poke it with a needle and drain it and put healing medicine on but it comes back and its turning hard and slowly going down and he has a open sore on his right leg on his heal and that one treat it, clean it and put healing rub on it and that too slowly going down..it turns to a scab and bear chews it off but it returns and like a dime in size and the one on his neck is like a quarter size...othen that he has joint issues and problem getting up so im giving him supplements for his hip and joints and muscles,tendons and blood flow to keep him walking ..

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Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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Pet Wellness Direct

Thank you for sharing Bear’s progress with us. 💛 We’re glad to hear you’re seeing some positive changes and appreciate how much care you’re putting into supporting his comfort and mobility. 🐶✨ We’re wishing Bear continued progress and many comfortable days ahead!

Reviewed by Lorraine M.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
7 - 10 Years
Dog Breed
Weimaraner
Pet Problem(s)
  • Inflammation
Will Consume Product
Devoured
Pet Happiness
Tail Wagging

Medicinal for healing

My dog has had an ongoing chronic toe infection for 3 years. Nothing would help cure it. Numerous rounds of antibiotics, which made her antibiotic resistant. I have tried over the counter remedies, home made concoctions, anything out of desperation. Nothing works. I decided to try critical immune Defense. She has finished just one bottle, and it is actually healing. I am so thrilled, I could cry. I highly recommend this product.

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Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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Pet Wellness Direct

Thank you for sharing your dog’s experience! 💛 After such a long journey, we’re so glad you’re seeing positive changes. 🐶✨ We truly appreciate your trust in Critical Immune Defense and your recommendation!

Reviewed by Sue C.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Boxer
Pet Problem(s)
  • Tumor
  • Limp
Will Consume Product
Enjoyed
Pet Happiness
Just Right

My dog is doing great!

We found out our boy Lennon had a meningioma tumor on his spine this Christmas. We decided not to operate as he's had enough emergency surgeries in his life. He turned 10 in June and is doing great thanks to Critical Immune Defense and all his other treats that he loves (as you can see in this video!) Thank you Pet Wellness Direct!

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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Pet Wellness Direct

Thank you for sharing Lennon’s story with us! 💛 We’re so happy to hear your 10-year-old boy is doing well and enjoying all of his favorite treats—it sounds like his personality is shining through in the video! 🐶✨ We’re honored that Critical Immune Defense is part of Lennon’s wellness routine and truly appreciate your trust in Pet Wellness Direct.

Reviewed by Sandy
Verified Reviewer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
7 - 10 Years
Dog Breed
Boxer
Pet Problem(s)
  • Joint Pain
  • Tumor
  • Stress
  • Cancer
  • Inflammation
Will Consume Product
Devoured
Pet Happiness
Just Right

Lymphoma and spleen cancer

My beautiful baby almost 10 year old girl Athena collapsed 2 weeks ago and was diagnosed with a lymphoma on her spleen believed to be cancerous. Due to her age, surgery is not an option. They are given us 4-6 months, but I refuse to give up! 2-3 days after her diagnosis her body went into severe distress. Lumps she didn’t have before started to grow. She had a marble size one between her eyes and one gum ball size in between her toes on her right paw.After doing much research I came across this supplement that reviewers claimed that it shrunk lumps. I started her on critical immune defense 2 weeks ago. Let me just say I cannot confirm that this supplement is doing anything to her internal lymphoma mass, PRAYING THAT IT IS! But I can confirm that after 1 week the lump in between her eyes has disappeared and after 2 weeks the lump in between her toes has shrunk about 80%. I don’t have a picture of how the lumps started, but these are after 2 weeks of her being on the supplement. I am shocked! I was thinking the worse, that they could be potential new cancerous tumors ready to burst and would have to take her for another vet visit. This supplement has given me hope. Will continue my baby on this supplement as so far nothing but good results.

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Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
Was this helpful?

Pet Wellness Direct

Thank you for sharing Athena’s story with us. 💛 We’re so sorry your beautiful girl and your family are facing such a difficult diagnosis. It’s encouraging to hear that you’ve noticed positive changes since adding Critical Immune Defense to her routine, and we truly appreciate you trusting us to be part of her care. 🐶✨ We’re wishing Athena comfort, plenty of good days, and many cherished moments with you.