Critical Immune Defense

Sale price$65.00 USD
Size: 1 Bottle

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1500 reviews
    • 5 Stars
      1239 Reviews
    • 4 Stars
      151 Reviews
    • 3 Stars
      77 Reviews
    • 2 Stars
      9 Reviews
    • 1 Star
      24 Reviews
    93% of reviewers would recommend this product to a friend
    Customer photos and videos
    1500 Reviews
    Reviewed by Hillary C.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Miracle in a bottle!

    Healing multiple symptoms and systems body wide! My senior feline is better in every way! This supplement has acted like a Fountain of Youth! Painful arthritis and joints - healing! Infected ears, bleeding from eyes - gone! After years of refusing to play, she's spunky and playful as a kitten! The product is soooo good that my husband and I have wondered if it could work for us! Worth every penny - we're on foodstamps, he's disabled and hence, I can only work part-time BUT WE WILL ALWAYS KEEP THIS SUPPLEMENT ON HAND! Deeply grateful and spreading the word. KEEP DOING WHAT YOU'RE DOING - WE LOVE YOU!

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    Pet Wellness Direct

    Hi Hillary, thank you so much for your heartfelt review! Your senior girl looks absolutely adorable in her photo, and we’re overjoyed to hear how much better she’s feeling—from easing her arthritis and ear infections to bringing out her playful kitten spirit again 🐾✨ It means the world to us that even with the challenges you and your husband face, you’ve made this supplement a must-have. Your love and dedication shine through, and we’re truly honored to be part of her healing journey. 💚

    Reviewed by Nicole D.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Cancer hasn’t returned

    My dog at 15 had a large lump removed that turned out to be cancerous . Where he was up there in years I opted to let him live out his golden years as happy as possible until , it was time to make that difficult choice (god forbid).

    Two years later my Cosmo is still happy and healthy, and the lump hasn’t returned . Can I say it’s solely because of this ? No, but can I say I am confident this helped in a major way? Yes. Other benefits include : his liver enzymes are back to normal range, and all of his major organ enzymes are within normal range. Cosmo will be 17 this October. Thank you vetsmart !

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    Pet Wellness Direct

    Thank you so much for sharing Cosmo’s incredible journey, Nicole! At nearly 17 years old, he looks absolutely amazing in his photo 🐾 We’re so happy to hear he’s still happy, healthy, and lump-free two years after his cancer diagnosis. It’s truly inspiring how his liver and organ enzymes have returned to normal—what a testament to your love and care. We’re honored that Critical Immune Defense has been part of Cosmo’s golden years!! 💙

    Reviewed by Jane B.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Great Dane
    Pet Problem(s)
    • Cancer
    Will Consume Product
    Devoured
    Pet Happiness
    Just Right

    Critical Immune Response

    This product is amazing. My 12 year old G Dane had several tumors that are no longer growing and are shrinking. Thank you for keeping my Lucy comfortable in her old age.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Jane! Thank you so much for sharing Lucy’s progress with us—what an incredible update! 🐾 At 12 years old, your sweet Great Dane looks absolutely beautiful in her photo, and we’re beyond happy to hear that her tumors have stopped growing and are even shrinking. That’s exactly the kind of comfort and support we hope to bring to senior dogs like Lucy. 💛

    Reviewed by Mary S.
    Verified Buyer
    Review posted
    Rated 3 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Labrador
    Pet Problem(s)
    • Cancer
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    I think it may be helping some

    My 9 yr old Labrador has osteosarcoma. She was diagnosed late March, and I found this Critical Immune Defense the same week. Started giving it to her about a week later. I'm not sure if it's having much of an effect, but I like to think it's helping a little. I'm going to keep giving it to her, and cross my fingers that it's helping. Her cancer has progressed, but maybe not as fast as it would have otherwise.

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    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Thank you for sharing, Mary. Your 9-year-old Labrador is absolutely beautiful, and we can see the love and hope in every word you wrote 🐾. Facing osteosarcoma is incredibly tough, but it’s clear you’re doing everything possible to support her. We’re honored to be part of her care and so glad you’re holding onto hope. Sending strength, and tail wags to both of you 💛.

    Reviewed by Chantelle M.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Pitbull Terrier
    Pet Problem(s)
    • Cancer
    • Low Energy
    • Joint Pain
    • Bad Breath
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Chopper loves it.

    Chopper loves the powder on his food. He licks the bowl clean. My Boy was recently diagnosed with Lymphoma. This product has helped him feel better, he plays more and eats better. We are hoping to get a few more months with him by using your product. Thank you for your interest in our babies.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Thank you so much for sharing, Chantelle. Chopper is such a handsome boy, and his photo radiates love and strength 🐾. We’re so glad to hear he’s enjoying the powder and feeling more playful and hungry again, even while facing lymphoma. Your care and devotion shine through, and we’re truly honored to be part of Chopper’s journey. Sending Chopper lots of belly rubs 💛.