Critical Immune Defense

Rated 4.7 out of 5
Based on 1223 reviews
Sale price$65.00 USD
Size: 1 Bottle
Free shipping on subscriptions AND all orders over $75

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1223 reviews
    • 5 Stars
      1010 Reviews
    • 4 Stars
      124 Reviews
    • 3 Stars
      61 Reviews
    • 2 Stars
      7 Reviews
    • 1 Star
      21 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    1223 Reviews
    Reviewed by Cheryl B.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Boxer
    Pet Problem(s)
    • Hip Pain
    • Joint Pain
    • Low Energy
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    There’s Renewed Hope!

    After 2/3 the way through our second bottle , we can see definite improvement in our 12-year-old Boxer, Bosley. He’s climbing stairs better, and can now lift his leg when urinating. I’m so very grateful for this!

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Thank you Cheryl for sharing Bosley’s progress! 🐾 It’s amazing to hear he’s climbing stairs and lifting his leg again—what a strong boy! 💙 He looks so handsome, and we’re thrilled Critical Immune Defense is helping him feel his best. Wishing you both continued health and happiness!

    Reviewed by Julie D.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Labrador
    Pet Problem(s)
    • Cancer
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    My dog loves it!

    We are 3/4 of the way through our first bottle, my dog loves the product and my vet has approved it . I feel like his lump has gotten smaller . We will find out next vet visit .

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Thank you Julie for sharing your Lab’s progress! 🐾 It’s great to hear he loves the product and that your vet approves. We’re hopeful for good news at his next visit, especially with signs that his lump may be smaller. 💙 He looks so happy and handsome!

    Reviewed by stacie s.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Labradoodle
    Pet Problem(s)
    • Cancer
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Its working!!!

    This product is amazing, my dog was diagnosed a couple months ago with Lymphoma. She was given 4 weeks. Everyone kept recommending the turkey tail mushroom, milk thistle and a couple other ingredients. This has all those in one product and has worked so well for my dog. She has improved so much, im on my 3rd order of this. She has a sensitive stomach and doesnt typically handle change well with her diet, this never bothered her! Order it you wont be disappointed!!!

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Stacie, thank you for sharing your Labradoodle’s incredible progress! 🐾 It’s amazing to hear how well she’s doing after her lymphoma diagnosis, especially with such a positive response to Critical Immune Defense. The fact that it’s gentle on her sensitive stomach and packed with everything she needs makes it even better! 💙 She sounds like such a strong and special girl, and we’re so happy she’s improving. Wishing you both continued health and happiness! 🐶✨

    Reviewed by Samantha K.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Australian Shepherd
    Pet Problem(s)
    • Cancer
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Freddie is Thriving

    My Australian Shepherd Freddie was diagnosed with osteosarcoma at the end of February 2024. His tumor was on his front right leg and with vet advisement the leg was amputated. Chemotherapy was discussed but I decided that treatment was not in Freddie's best interest. I was warned that with only amputation dogs with osteosarcoma usually only survive for 3-6 months after surgery. I happened to come across this product on Facebook. After reading all the reviews I decided to give it a try and I believe it has helped Freddie immensely. Freddie is now entering his 10th month post surgery. He is still full of energy and life. He is such a happy dog! He had a check up with the vet a couple weeks ago and I was told to keep doing what I am doing! They also said it is inspiring how well Freddie is doing after his cancer diagnosis. I know that the likelihood of this cancer coming back is high but I am so grateful for everyday we get to have together and I truly believe that critical immune defence has played a major role in that. I am a big believer in this product!

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Samantha,
    Thank you for sharing Freddie’s incredible journey! 🐾 It’s inspiring to hear how well your sweet Australian Shepherd is doing 10 months post-surgery, especially with his energy and happiness shining through. Your love and care, paired with Critical Immune Defense, are clearly making a difference. 💙 Freddie’s resilience and joy are truly heartwarming, and we’re so glad you’ve had these extra, precious moments together. Please give him an extra belly rub from us—he’s such a fighter! 🐶✨

    Reviewed by Teri S.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Other
    Pet Problem(s)
    • Overweight
    • Tumor
    • Inflammation
    • Hip Pain
    • Stress
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    Doja

    Doja is a gator pit bull she seem to be playing more I only give it to her once a day the vet told me that she’s concerned about something with copper I didn’t ask what that means.

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    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Teri, thank you for sharing Doja’s progress with us! 🐾 It’s wonderful to hear she’s playing more and enjoying herself—that’s such a great sign. She’s a beautiful gator pit bull, and it’s clear how much love and care you’re giving her. 💙 We’re here to support you and Doja on her journey!