Critical Immune Defense

Sale price$65.00 USD
Size: 1 Bottle

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1410 reviews
    • 5 Stars
      1170 Reviews
    • 4 Stars
      141 Reviews
    • 3 Stars
      68 Reviews
    • 2 Stars
      9 Reviews
    • 1 Star
      22 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Customer photos and videos
    1410 Reviews
    Reviewed by Charles R.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Limp
    • Tumor
    • Inflammation
    Will Consume Product
    Enjoyed

    Barts lumps

    So far the two lumps are starting to get smaller . I’ll need couple more months to give final grade

    Loading...
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Charles, great news about Bart! 🐶💙 It’s wonderful to hear his lumps are shrinking—your dedication is paying off! He looks fantastic in his photo, and I hope he continues to improve. 💕 Please keep us posted!

    Reviewed by Jeanne M.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    5 - 7 Years
    Dog Breed
    Mixed Breed
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Preventive use

    I am using Critical Immune Defense as a preventive measure to strengthen her immune system and ward off problems before they start. I have just started seeing a holistic vet and she is thrilled with what I’m doing.

    Loading...
    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Jeanne, it’s fantastic to hear! 💙🐶 Taking a proactive approach to your pup’s health is such a smart decision, and it’s wonderful that your holistic vet is thrilled with what you’re doing. Supporting her immune system now can make a big difference in the long run! She must look absolutely adorable in her photo—wishing you both continued health and happiness on this journey! 💕

    Reviewed by Lisa R.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Mixed Breed
    Cat Breed
    Other
    Pet Problem(s)
    • Overweight
    • Limp
    • Tumor
    • Low Energy
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Natural & Made in the USA!

    All three of our dogs and 1 cat take this daily. They have more energy, no more itchy skin, (also changed diet to homemade), and our dog Franklin has less health issues at 9 years old. Along with this daily, we do homemade food, red light therapy once a week and plenty of exercise. This supplement gave him back his energy so he could be active again. He was scheduled to have ACL surgery and cleared by the doctor not to! We tribute that to not only the measures we’ve taken, but the supplement! Our cat Moo was found as a kitten with his face smashed. This caused sinus issues with seasonal changes. We just started him on the Immune Defense. Thank you so much for creating it! We’re also getting ready to order the digestive supplement.

    Loading...
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Lisa, what an amazing transformation for Franklin and Moo! 🐶🐱 It’s incredible that Franklin regained his energy and even avoided ACL surgery—such a huge win! Your dedication, from homemade meals to red light therapy, is truly inspiring. They all look fantastic, and we’re so happy Critical Immune Defense is helping. Wishing them continued health and happiness! 💙💕

    Reviewed by Margaret L.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    5 - 7 Years
    Dog Breed
    Mixed Breed
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Great product!

    I like knowing I'm giving my dog a supplement that might help through his senior years.

    Loading...
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Margaret, That’s wonderful! 🐶💙 Your senior pup is lucky to have you looking out for his health. Wishing you both many happy, healthy years ahead! 💕

    Reviewed by Margaret C.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    3 - 5 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Inflammation
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Baby Steps

    My dog has allergies, yeast issues (over his entire undercarriage) and, if scratched, gets staph. He has the absolute worst skin issues. Vet put him on Apoquil when he was less than a year old, at the highest dose twice a day. He was on it for about 2 1/2 years. ( It’s only approved for two weeks at that dose.) I started noticing his yeast problem was spreading, all over his sides. I did research, stopped the Apoquell and have been fighting this issue ever since! A new vet has him on regular Cytopoint shots, but in the beginning he was on steroids, etc.

    Since I started a regimen of Probiotics, his stools got better, but since also adding the Critical Immune Defense, I can actually pick up his stools easily AND he just overall feels better! He’s back to playing with our other dog, a 3 year old Rottweiler! He has more energy and is more like the old Rocky!

    He looks like he’s at least 9 or 10 years old from his health issues and he’s only 5, so I’m still working to improve his terrible condition. Having trouble getting his hair to grow back on his sides, but working on it!

    Loading...
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Margaret, Wow, what an incredible journey you and Rocky have been on! 🐶💙 It’s heartbreaking to see a young dog struggle with such severe skin issues, but your dedication to finding a better solution is truly inspiring. Seeing his energy return, his stools improve, and him back to playing with your Rottweiler is such a huge win! Baby steps add up, and it’s amazing that he’s starting to feel more like his old self. He looks so handsome in his video, and with your love and persistence, I’m sure his coat will continue to improve. Wishing Rocky even more healing and happy, itch-free days ahead! 💕