Critical Immune Defense

Sale price$65.00 USD
Size: 1 Bottle

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1401 reviews
    • 5 Stars
      1163 Reviews
    • 4 Stars
      140 Reviews
    • 3 Stars
      67 Reviews
    • 2 Stars
      9 Reviews
    • 1 Star
      22 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    1401 Reviews
    Reviewed by Margaret L.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    5 - 7 Years
    Dog Breed
    Mixed Breed
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Great product!

    I like knowing I'm giving my dog a supplement that might help through his senior years.

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    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Margaret, That’s wonderful! 🐶💙 Your senior pup is lucky to have you looking out for his health. Wishing you both many happy, healthy years ahead! 💕

    Reviewed by Margaret C.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    3 - 5 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Inflammation
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Baby Steps

    My dog has allergies, yeast issues (over his entire undercarriage) and, if scratched, gets staph. He has the absolute worst skin issues. Vet put him on Apoquil when he was less than a year old, at the highest dose twice a day. He was on it for about 2 1/2 years. ( It’s only approved for two weeks at that dose.) I started noticing his yeast problem was spreading, all over his sides. I did research, stopped the Apoquell and have been fighting this issue ever since! A new vet has him on regular Cytopoint shots, but in the beginning he was on steroids, etc.

    Since I started a regimen of Probiotics, his stools got better, but since also adding the Critical Immune Defense, I can actually pick up his stools easily AND he just overall feels better! He’s back to playing with our other dog, a 3 year old Rottweiler! He has more energy and is more like the old Rocky!

    He looks like he’s at least 9 or 10 years old from his health issues and he’s only 5, so I’m still working to improve his terrible condition. Having trouble getting his hair to grow back on his sides, but working on it!

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    Pet Wellness Direct

    Hi Margaret, Wow, what an incredible journey you and Rocky have been on! 🐶💙 It’s heartbreaking to see a young dog struggle with such severe skin issues, but your dedication to finding a better solution is truly inspiring. Seeing his energy return, his stools improve, and him back to playing with your Rottweiler is such a huge win! Baby steps add up, and it’s amazing that he’s starting to feel more like his old self. He looks so handsome in his video, and with your love and persistence, I’m sure his coat will continue to improve. Wishing Rocky even more healing and happy, itch-free days ahead! 💕

    Reviewed by Laura S.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Tumor
    • Inflammation
    • Stress
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    No longer skeptical

    I bought this for my sister's blind older pit bull who was covered with lumps and bumps. The dog has no eyes (born that way) but some kind of "growth" that none of her vets could identify kept growing out of one eye socket..... My sister is always skeptical of things I send her to alleviate various situations with her and her dogs. I told her to just try it with Miss Frances, who is a doll and doesn't deserve to suffer with things growing all over her and out of her. So, I am sure reluctantly, my sister started treating Miss Frances. It's taken several weeks BUT.....

    "I also think that the immunity booster that my sister got for her has really done a number on the skin tags and hair folical cysts have really changed. It's been around 6 weeks that she's been on it, and I can't factor that out of the equation in terms of her getting back in bed with us." AND a few weeks later.....

    "I am really pretty pleased with how Frances is doing. That powder my sister got her that is an immune booster certainly seems to be doing something. I thought sure that growth would be popping our her eye by now and it is not even showing. That's exciting."

    My sister is now looking forward to more time with Miss Frances, instead of sobbing over the idea that nothing can be done, and my sister will lose another large part of her heart.......

    This stuff is AWESOME! If you're on the fence about purchasing it for your animal, err on the side of trying it! It's made a HUGE difference for us!

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    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Laura, Wow, what a transformation for sweet Miss Frances! 🐶💙 It’s amazing that your persistence helped your sister give this a try, and now she’s seeing real improvements. Six weeks in and those stubborn growths are changing—that’s incredible! Knowing Miss Frances is feeling better and back in bed with her family is the best news. She is beautiful, and it’s clear she’s so loved. Wishing her continued health and happiness! 💕

    Reviewed by Jamie B.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5
    Pet Age
    7 - 10 Years
    Cat Breed
    Mixed Breed
    Pet Problem(s)
    • Inflammation
    Will Consume Product
    Nibbled

    Using with FIV Kitty - Hopeful for Longer Term Results

    I purchased this for my 8-year old tabby cat who is FIV positive. It's a preventative measure to help boost his immune system. He has a consistent upper respiratory "sniffle" and I'm hoping, over time, this supplement will help. Antibiotics knock it out but it always comes back in time. I believe this supplement will take time because when we had a few of his teeth removed, it was a very, very slow recovery process. I am curious if anyone else has used this supplement to help the overall health of cats with FIV. I have looked online but have not seen any reviews or comments to help aid this condition. I gave four stars because it can be hard to get him to eat it. I cannot give the full 1/2 tsp at any meal. I have to break it into 1/4 portions and feed in small batches. I'm currently hiding it in his grain-free wet food. I think he smells it. I also sprinkle it on his dry food and shake it, and it coats it.

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    Pet Wellness Direct

    Thank you Jamie for sharing your experience with Critical Immune Defense for your 8-year-old tabby! 🐱 It’s clear you’re deeply committed to his health, and your creative approach to mixing the supplement into his food is impressive. FIV can be challenging, but your patience and dedication will surely make a difference. Hopefully, over time, his sniffles improve, and his immune system gets stronger. He looks absolutely adorable in his photo—such a lucky kitty to have you! 💙

    Reviewed by Valerie H.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Labrador
    Pet Problem(s)
    • Inflammation
    • Joint Pain
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    Critical immune defense

    I have a 10 yr old Lab & she has stayed very healthy while on this immune defense . My vet also swears by it for her dogs

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    Pet Wellness Direct

    Thank you Valerie for sharing your Lab’s experience! 🌟 It’s wonderful to hear that at 10 years old, she’s staying healthy with Critical Immune Defense. 🐾 Your picture and video is terrific! It’s also great to hear that your vet swears by it too. Wishing you both continued health and happiness! ❤️