Critical Immune Defense

Rated 4.7 out of 5
Based on 1035 reviews
Sale price$65.00 USD
Size: 1 Bottle
Free shipping on subscriptions & orders $75 or more.

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Your Pet's Immune System Is the Key to Its Health

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet. Let’s face it. Your dog and cat lives in a world filled with contamination. They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants. The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful.

    Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health. Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

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    50%

    Cancer Rates are skyrocketing

    More dogs and cats are being diagnosed with cancer than ever before.

    According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    “One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

    Pet Owners CAN Make A Difference

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

    Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and mmunomodulatory properties that may help fight cancer and certain other diseases.”

    - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    More dogs and cats are being diagnosed with cancer than ever before.

    According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    “One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

    Pet Owners CAN Make A Difference

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

    Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and mmunomodulatory properties that may help fight cancer and certain other diseases.”

    - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    The doctors agree

    Dr. Frank Markland

    Professor of Biochemistry and Molecular Medicine at the University of Southern California Keck School of Medicine.

    Dr. Shawn Messonnier

    Veterinary Medicine and author of "The Natural Vet's Guide to Preventing and Treating Cancer in Dogs"

    Dr. Jennifer Edwards

    Ponemah Veterinary Hospital

    Where you have seen us

    Critical Immune Defense

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    The all-natural solution. Trusted by veterinarians.

    Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

    Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Frequently Asked Questions

    Happy Customer Reviews

    average rating 4.7 out of 5
    Based on 1035 reviews
    • 5 Stars
      860 Reviews
    • 4 Stars
      104 Reviews
    • 3 Stars
      50 Reviews
    • 2 Stars
      7 Reviews
    • 1 Star
      14 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    1035 Reviews
    Reviewed by Michelle W.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Labrador
    Pet Problem(s)
    • Limp
    • Tumor
    • Inflammation
    • Joint Pain
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    My older labs lumps dissolved

    We have seen a huge change in the size of the lumps on our 12yr old lab since using this product for about 6months

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Michelle! Thank you for sharing the wonderful progress your 12-year-old Lab has made with Critical Immune Defense. It's fantastic to hear that the lumps have significantly reduced in size over the past six months. Your Lab looks beautiful in the photos and video, and seeing such positive results is heartening. Your dedication to their health and well-being is truly inspiring. 🐾💖

    Reviewed by Susan W.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Basset Hound
    Pet Problem(s)
    • Bad Breath
    • Low Energy
    • Joint Pain
    Will Consume Product
    Nibbled
    Pet Happiness
    Tail Wagging

    Amazing Transformation

    I ordered the Critical Immune Defense for my Bagel girl Marmalade. She lost her older Basset Hound brother last year who was 16 and was starting to show signs of depression since she was now the only dog. She also turned 13 (now she is a teenager) in April so I thought the product would help protect her health. For a couple of months there was not a big change but by month three I could see a difference. She was perkier, eating better and back to her usual mischievous self.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Susan! Thank you for sharing Marmalade's amazing transformation! We're so glad our Critical Immune Defense has helped your 13-year-old Basset Hound regain her perkiness and appetite. Marmalade looks absolutely adorable in the photo, and it's wonderful to see her back to her mischievous self. Your dedication to her well-being is truly inspiring. 🐾💖

    Reviewed by LouAnn C.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    3 - 5 Years
    Dog Breed
    Boston Terrier
    Pet Problem(s)
    • Tumor
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Histiocytoma

    My Boston terrier at 5 yrs of age developed a large tumor on his neck, where his collar sat. While not malignant, it had to be surgically removed. He has also had severe hives reactions with his annual vaccines in the past. One year after his surgery for histiocytoma, he began to develop multiple growths on his head and back which looked similar to his original growth. The vet advised that this was most likely the same type of growth as he appears to be very reactive. Following a steroid shot, I began to use Critical Immune Defense and the multiple growths disappeared in a few weeks. I have kept him on it since, with no further problems. I also give it to my nearly 15 yr. old Sheltie, who has had awful dental problems and horrible breath. That seems to be improving some as well. I am very satisfied with your product and intend to keep using it.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Thank you, LouAnn, for sharing your pup's journey with us! We're thrilled to hear how Critical Immune Defense swiftly resolved his histiocytoma growths, and seeing him so happy and healthy in the photo you shared warms our hearts. It's also great to hear about your senior Sheltie's dental health improvements. We're here to support you and your furry family members always!

    Reviewed by Terry H.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Labrador
    Pet Problem(s)
    • Low Energy
    • Inflammation
    • Hip Pain
    • Joint Pain
    • Limp

    Critical immune Defense

    Both our dogs are big an they just didn't seem really excited anymore. One is a 10yr old lab an other is a mix of saint Benard he's 8yrs old. Once we started giving them this immune defense they are playing more now.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Terry, Thank you for sharing your experience! It's wonderful to hear that your 10-year-old Lab and 8-year-old Saint Bernard mix are more energetic and playful. The pictures of your dogs are adorable! We're so glad Critical Immune Defense has helped. 🐾❤️

    Reviewed by Jane F.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    5 - 7 Years
    Pet Problem(s)
    • Joint Pain
    • Inflammation

    Tight cervicals

    My little chi/doxi mix has back issues, especially in his neck. I put him on Critical Immune Defense about a year ago and his bouts with neck pain have diminished greatly! All 3 dogs and 8 cats are on this product. It’s palatable and easy to feed. Highly recommend!!

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Jane, Thank you for sharing your positive experience with Critical Immune Defense! It's wonderful to hear your Chi/Doxi mix's neck pain has greatly diminished. Your dedication to all your pets is inspiring. The pictures of your pets are adorable! We're glad our product has made a difference. 🐾❤️