Critical Immune Defense

Rated 4.7 out of 5
Based on 1210 reviews
Sale price$65.00 USD
Size: 1 Bottle
Free shipping on subscriptions AND all orders over $75

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1210 reviews
    • 5 Stars
      1000 Reviews
    • 4 Stars
      121 Reviews
    • 3 Stars
      61 Reviews
    • 2 Stars
      7 Reviews
    • 1 Star
      21 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Customer photos and videos
    1210 Reviews
    Reviewed by Teri S.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Other
    Pet Problem(s)
    • Overweight
    • Tumor
    • Inflammation
    • Hip Pain
    • Stress
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    Doja

    Doja is a gator pit bull she seem to be playing more I only give it to her once a day the vet told me that she’s concerned about something with copper I didn’t ask what that means.

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    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Teri, thank you for sharing Doja’s progress with us! 🐾 It’s wonderful to hear she’s playing more and enjoying herself—that’s such a great sign. She’s a beautiful gator pit bull, and it’s clear how much love and care you’re giving her. 💙 We’re here to support you and Doja on her journey!

    Reviewed by Pamela M.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5
    Pet Age
    3 - 5 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Cancer
    • Tumor
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    Hoping Critical Immune Defense will help my pittie mix fight cancer.

    My 3 year old pitta mix is a rescue and has been through 2 rounds of heart worm treatment since I rescued her in January, 2022. This spring I noticed a lesion on her belly that resembled a blood blister. I tried to drain it but it would fill back up, so I took her to the vet. They told me them didn't know what is was and recommended that it be surgically removed. The surgery was done and the growth was sent for pathology. It came back as malignant - dermal hemangiosarcoma. Two weeks after her incision was healed, the tumor was back. More surgery was done to get wider margins.

    Her prognosis is guarded. The type of cancer she has is very aggressive if it is found in any internal organs - lungs, spleen, liver or heart. So I had x-rays and ultrasound scans of her abdominal area and her lungs done, which thankfully were clear. At that point I started to looking for anything I could do to help her fight spread of the disease. I talked to my vet about Critical Immune Defense and he was familiar with the product and said that it certainly could not hurt her and very possible will be beneficial. I started giving CDI to her, with both meals, about a month ago. I just sprinkle it over her kibble and she eats it right up. There are no signs of new tumors on her skin. We will be getting another set of x-rays and scans in 2-3 months. Please say a prayer for my girl. I am hopeful the new scans will also be clear!

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Pamela, Thank you for sharing your sweet pittie mix’s story. We’re so glad Critical Immune Defense is part of her journey, and it’s encouraging to hear she’s doing well with no new tumors on her skin. She’s such a fighter! 🐾💙 Your story has the power to make a difference, and we truly appreciate you! Please keep us posted on your pups health journey.

    Reviewed by Helen R.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Labradoodle
    Pet Problem(s)
    • Overweight
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Awesome supplement!

    My Toby loves this sprinkled on his kibble and mixed with a few drops of water! He thinks it’s like Thanksgiving gravy! Little does he know it’s really keeping him healthy. Although his lumps are still there, they don’t seem to bother him. He’s almost 12 and acting like a puppy!

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    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Thank you, Helen! Toby looks adorable, and it’s great to hear he loves his “Thanksgiving gravy.” 🦴 At nearly 12, it’s amazing he’s staying so playful and active. 🎉 You’re doing an incredible job—Toby’s lucky to have you! 🐾

    Reviewed by bob r.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Shih Tzu
    Pet Problem(s)
    • Cancer
    • Tumor
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    Loves the flavor

    My Lulu has mast cell cancer and has gone through 5 surgeries with the last one being lymph node removal. Been using this product mixed with CBD oil and pumpkin to help keep her immune system strong and healthy. So far so good. Thank you for your great product.

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Thank you for sharing Lulu’s journey! 🐾 It’s amazing to hear she’s doing well after multiple surgeries and loves the flavor of Critical Immune Defense. She looks adorable, and we’re so glad it’s helping keep her strong! 💙 Wishing you both continued health!

    Reviewed by Patricia B.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Miniature Schnauzer
    Pet Problem(s)
    • Cancer
    • Tumor
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Happy boy

    I started immune defense after my boy had a spleenectomy last yr. He has since been diagnosed with Tcc (bladder cancer) this past April. He seems to have more energy when taking immune defense. On days that someone else feeds him and forgets his powder he doesn't seem as energetic. So I'd say that seems to be biggest thing I notice. We are also 7 months past diagnosis and still going well.

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Patricia, thank you for sharing your Miniature Schnauzer’s journey! 🐾 It’s amazing to hear he’s still going strong 7 months after his diagnosis and has more energy with Critical Immune Defense. He looks like such a happy, resilient boy! 💙 Wishing you both many joyful days ahead!