Critical Immune Defense

Rated 4.7 out of 5
Based on 1200 reviews
Sale price$65.00 USD
Size: 1 Bottle
Free shipping on subscriptions AND all orders over $75

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1200 reviews
    • 5 Stars
      993 Reviews
    • 4 Stars
      119 Reviews
    • 3 Stars
      60 Reviews
    • 2 Stars
      7 Reviews
    • 1 Star
      21 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    1200 Reviews
    Reviewed by suzanne m.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Pet Problem(s)
    • Bad Breath
    • Low Energy
    • Stress
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Addy and Emmie

    My girls are my life! Since taking Pet wellness. They seem more energetic. They are 9 and 7. Shiny coats and little to none paw licking!

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Suzanne, Thank you for sharing, and for trusting Critical Immune Defense with your girls, Addy and Emmie! 🐾 It’s wonderful to hear they’re more energetic, with shiny coats and less paw licking—that’s such great progress! They look absolutely beautiful in their video, and it’s clear they’re living their best lives thanks to your loving care. 💙 Here’s to their continued health and happiness!

    Reviewed by Debbie M.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Dachshund
    Pet Problem(s)
    • Overweight
    • Inflammation
    • Bad Breath
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    12 year old dachshund is moving better

    My 12 year old dachshund has shown improvements in his mobility, weight and fatty body bumps. He's happier and very frisky ;)

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Debbie, Thank you for sharing your sweet boy’s progress! 🐾 It’s fantastic to hear that your 12-year-old Dachshund is moving better, shedding some weight, and seeing improvements with those fatty bumps. He must feel so much happier —what a joy to see him thriving! He looks absolutely adorable in his picture. 💙 Wishing you both continued health and playful days ahead!

    Reviewed by Marina B.
    Verified Buyer
    Review posted
    Rated 3 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Low Energy
    • Stress
    • Hip Pain
    • Joint Pain
    • Inflammation
    Will Consume Product
    Devoured
    Pet Happiness
    Just Right

    Good product

    Product ships in a timely matter. Our pooches love the taste. On our 2nd bottle, but haven't seen any diff yet. Will give it another month...

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    Effectiveness
    Rated -2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Marina, Thanks for sharing your experience! 🐾 Glad to hear your pooches love the taste! Sometimes it takes a bit longer to see results, especially with joint and inflammation issues. Your picture looks adorable, and we’re hopeful for improvements soon. 💙 Keep us updated!

    Reviewed by Sherri P.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Other
    Pet Problem(s)
    • Limp
    • Inflammation
    • Cancer
    • Joint Pain
    Will Consume Product
    Devoured

    Awesome Product

    Your product is amazing. My dog Ben had bone cancer was diagnosed in March. They didn’t give him much time. I started him on your product and I got 5 1/2 months more with him. I lost him on October 3. He is now cross the rainbow bridge but my other two dogs I have on it thank you so much.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Thank you, Sherri, for sharing Ben’s journey with us. We’re truly honored that Critical Immune Defense gave you those extra months together. 🌈 His strength shines in his photo, and we’re glad to know your other two dogs are also benefiting. Thank you for trusting us with your pets' wellness. 🐾

    Reviewed by Carla W.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Pitbull Terrier
    Cat Breed
    Mixed Breed
    Pet Problem(s)
    • Limp
    • Joint Pain
    • Low Energy
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Molly, Sammie, Stormie and Quincy the Cockatoo

    I’ve had both dogs on Immune defense for several years and I m currently out because I had it sent to the wrong address so it is being forwarded. We are traveling in our 5th wheel and I have to get to a place we will stay awhile so I can reorder. I do notice a big difference in both dogs since we’ve been out. I need to get them back on asap. Thank you

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Was this helpful?

    Pet Wellness Direct

    Hi Carla! 😊 Thank you for sharing your pet's journey with Critical Immune Defense. It’s wonderful to hear how much it’s helped them, and we can’t wait to get them back on it! Safe travels in your 5th wheel, and give those cuties a hug from us! 🐾