Critical Immune Defense

Sale price$65.00 USD
Size: 1 Bottle

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1370 reviews
    • 5 Stars
      1142 Reviews
    • 4 Stars
      133 Reviews
    • 3 Stars
      65 Reviews
    • 2 Stars
      9 Reviews
    • 1 Star
      21 Reviews
    93% of reviewers would recommend this product to a friend
    1370 Reviews
    Reviewed by Cortney W.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5

    Seems to be helping!

    I have been giving this to my 4 year old bullmastiff to help his overall health. He enjoys it in his raw diet and I have noticed his coat shinier and softer. I have also noticed that he seems happier and more comfortable. I haven’t changed anything else in his diet so I am assuming this is making him feel better. He doesn’t have any health issues, just some acid reflux. Because of his size, he needs 6 scoops a day, it makes it a very expensive supplement. That’s my only concern.

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    Pet Wellness Direct

    Thank you Cortney for sharing your Bullmastiff’s progress with us! 🌟 It’s wonderful to hear how much shinier and softer his coat has become and that he’s happier and more comfortable overall. 🐾 His video shows what a handsome and healthy boy he is! We’re glad he’s enjoying it in his raw diet and love hearing how it’s contributing to his well-being. We truly appreciate your dedication to his health. ❤️

    Reviewed by Mark N.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Cancer Improvement

    Our 13 year old border mix rescue dog, Buffy, was diagnosed with mast cell cancer just over a year ago. We had a large lump removed but several smaller ones started coming up. After one month on the Critical Immune Defense the lumps have noticeably shrunk. I have shared the results with my vet and they are very interested in being kept updated.

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    Pet Wellness Direct

    Thank you Mark, for sharing Buffy’s incredible progress! 🌟 At 13 years old, she’s such a brave and resilient girl, and it’s wonderful to hear how Critical Immune Defense has helped shrink her lumps. 🐾 Her picture is absolutely adorable, and it’s clear how much love and care she receives. We’re so glad your vet is interested in her journey, and we’re wishing Buffy continued improvement and many happy days ahead! ❤️

    Reviewed by Susan R.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Change in cancerous tumors.

    I have a 12 year-old corgi who had some large lumps on her belly and a friend recommended Critical Immune Defense. I started giving it to my corgi about 6 weeks prior to surgery. The pathology report had come back with both lymphoma and melanoma cells evident in the tumors. However just two days ago when the tumors were removed both were solid fatty tumors with no abnormal cells. Not sure what part Critical Immune Defense played in this good news but I am definitely going to continue it as a part of my dogs daily food intake. Truthfully it has her acting like a puppy again her energy and love of life are amazing.

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    Pet Wellness Direct

    Hi Susan, Thank you for sharing your corgi’s incredible story! 🌟 It’s amazing to hear about the change in her tumors and how she’s acting like a puppy again. 🐾 Her picture shows such a vibrant, sweet soul. Wishing you both many more happy, healthy days together! ❤️

    Reviewed by Linda W.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Recommend by a friend when Sarah’s tumor was found.

    On November 8, 2024 Sarah had her spleen removed when an almost 2 pound tumor was found during an ultrasound. The spleen and tumor were sent in for a biopsy and came back positive for hemangiosarcoma.

    A friend of mine recommended Critical Immune Support, and suggested I read the reviews. I decided to put Sarah on it a few days after her biopsy results came back. I was told when the results were in that the average dog lives about 6 to 8 weeks after diagnosis. It was eight weeks since her surgery on January 3, 2025.

    I am giving her her third bottle of the Critical Immune Defense Support. She has been eating it mixed into her food, really well with the exception of a few days here and there where she felt sick and skipped breakfast. I found that if she doesn’t want to eat her raw food with the mushrooms mixed in it, she will eat it mixed into canned dog food a couple hours later though.

    I have plans to continue to buy this product for as long as I can. Each day is a gift. She seems like she feels so much better since she’s been taking it and almost appears to be not sick at all. I believe it’s doing something to help her!

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    Pet Wellness Direct

    Thank you Linda so much for sharing Sarah’s incredible journey! 🌟 At such a challenging time, your love and care shine through, and it’s heartwarming to hear how Critical Immune Defense has made such a difference for her. 🐾 Her pictures and videos show such a beautiful, resilient spirit, and it’s amazing that she’s feeling so much better and enjoying life. Each day truly is a gift, and we’re honored to be part of Sarah’s journey. Wishing you both many more moments of joy together! ❤️

    Reviewed by Nancy R.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Carly’s new health

    Carly had a lump about the size of a golf ball. This is my 2nd month on CID. Very happyto report her lump has shrank. Very hopeful it goes completely away. It was hanging. Now

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    Pet Wellness Direct

    Hi Nancy, Thank you for sharing Carly’s progress with us! 🌟 It’s incredible to hear how much her lump has shrunk after two months on Critical Immune Defense.🐾 You’re doing an amazing job supporting her health—wishing you both all the best on this journey! ❤️