FIGHT VIRUSES, DISEASES, AND CANCERS.

Critical Immune Defense for Dogs & Cats

Sale price$65.00 USD
Size: Small Bottle | 70 Scoops

There simply isn't another product of this quality and strength - with THOUSANDS of testimonials about the results - available on the market!

Critical Immune Defense is a safe, all-natural immune booster that can add years to the life of your dog or cat.

Made in the USA with certified organic mushrooms.

✔︎ Boosts immune system

✔︎ Reduces inflammation

✔︎ Promotes normal cell growth

✔︎ Protects against toxins in food, water & environment

✔︎ Supports long-term health in both cats and dogs

Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

"Wish there was a human version!! Our large male German shepherd was getting growths on his neck and by his eye. They were getting larger. I saw this product and ordered one canister, not expecting much. However, within 2 weeks, the growths were getting smaller. They finally disappeared! We now give this as a preventative to both of our dogs! Highly recommend it!! Worth the money!!" - Carla

“My cat is 15 and has feline herpes. In the past, I have given her lysine with very little results. Since taking Critical Immune Defense I have seen a steady improvement. Hardly any eye discharge and her nose isn’t wet anymore. No difficulty breathing at all. My son said, “What took you so long to find this stuff?” I also give it to my 3-year-old dog, she’s healthy but …..just in case. They both eat it and have no problem eating all their food.” - Lisa

"This supplement has saved my dog’s life. She is a completely different animal, now. She’s an 11-year-old Maltipoo and was diagnosed with lymphoma last April. She was on chemotherapy, and this supplement along with a healthy greens supplement for 3 months, and her cancer is gone. I have kept her on these supplements, and they continue to work miracles in her little body. She also used to have the worst skin issues, constantly having things removed, and she was just generally not healthy. It’s unbelievable how healthy, happy, and energetic she is. It truly is a miracle!" - Adelle

“I have a rescue and keep 8 senior and special needs cats. I give them this for cats, and it has proven to extend the lives of those who were in danger of losing their lives from cancer, renal failure, and, frankly, only God knows what else! I am grateful for this formula being available for seniors we adore and aren’t really ready to cross the 🌈 yet❣️👍😻 This was Foxy Loxy. He had been failing(14 yrs old), but as he received Pet Wellness Support, he recovered his enjoyment of life, and I could love him for 2 more years❣️ I have other kitties' who had experienced similar recoveries through Pet Wellness. Thank you again!”❣️- Mat

Your pet's immune system is the key to its health! Here's why:

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it. Your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive!

Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

Your pet's immune system is the key to its health! Here's why:

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it. Your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive!

Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

Key Ingredients

Organic Turkey Tail Mushrooms

This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

✔︎ Delivers significant amounts of tumor-fighting Polysaccharopeptides (PSPs)

✔︎ Approved by the United States Food & Drug Administration for use in treating prostate and breast cancer in humans

✔︎ Proven to delay the growth of cancerous tumors in dogs and improve their survival rate

Organic Reishi Mushrooms

This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

✔︎ Contains beta-glucans that increase the immune system’s T-cell levels

✔︎ Lowers inflammatory responses caused by stress, poor diet, and other environmental factors

✔︎ Contains ganoderic acids that have been shown to lower cholesterol levels and blood pressure

Organic Shiitake Mushrooms

According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

✔︎ Contains all 8 essential amino acids as well as linoleic acid, an essential fatty acid

✔︎ Used in Japan to treat heart disease, hepatitis, high blood pressure, and infectious diseases

Organic Maitake Mushrooms

Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

✔︎ Contains beta-1, 6 glucan polysaccharide components that stimulate the immune system and reduce abnormal cell growth

✔︎ Used in Asia to help minimize the toxic effects of radiation and chemotherapy treatment

White Turmeric Root Extract

Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and liver damage.

Our proprietary extract is six times more bioavailable than standard turmeric root, which means it’s more effectively absorbed into your pet’s body and they need less of it to get the same effect. It’s also colorless and milder tasting, making it easier to handle -- and tastier for your pet! No more turmeric stains!

The doctors agree.

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

More cats and dogs are being diagnosed with cancer than ever before. 

“Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

Your pet’s immune system is one of the most critical parts of its health.

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Your pet’s immune system is one of the most critical parts of its health.

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Not only is it easy to use (just sprinkle it over your pet’s food) -- your pet will love the taste!

Scoops/Bottle: 70 Small | 210 Large

NEW Enhanced Formula

Discover Our Enhanced Formula!

We've improved our formula! The new product may appear lighter in color and have a slightly different texture (but the same great taste), thanks to our innovative use of the fruiting body and mycelium of the four mushrooms, instead of mushroom extracts.

 Why the Change?

Traditional mushroom extracts are processed using heated water, which is then sprayed to create a powder. Our research suggests that this heat processing can diminish the valuable nutrients in the mushrooms.

Understanding Fruiting Body and Mycelium

Fruiting Body: This is the part of the mushroom you're familiar with—the cap and stem.

Mycelium: These are the nutrient-packed roots and base of the mushroom.

We use the entire mushroom, grinding it into a nutrient-dense powder that boasts higher levels of beta-glucans and polysaccharides than extract powders. Independent testing has shown that our new mushrooms contain up to 250% more beta-glucans and polysaccharides.

Research-Backed Benefits

According to research published by the National Library of Medicine, beta-glucans and polysaccharides are renowned for their metabolic and immunomodulatory properties, including anticancer, antibacterial, and antiviral effects. In some countries, the mushrooms we use in Critical Immune Defense are prescribed not only to prevent cancers and diseases but also to effectively treat them.

Organic and Sustainable

Our mushroom blend is organically grown in Canada on sustainable farms using patented and breakthrough growing processes to enhance the full spectrum of bioactive compounds. It doesn't get any better for your pet!

Experience the powerful benefits of our enhanced formula and give your pets the best in health and wellness!

Made in the USA to the highest quality standards.

VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved pet’s health.

Frequently Asked Questions

average rating 4.8 out of 5
Based on 1457 reviews
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96% of reviewers would recommend this product to a friend
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Customer photos and videos
1457 Reviews
Reviewed by Martha S.
Verified Buyer
Review posted
I recommend this product
Rated 4 out of 5
Pet Age
7 - 10 Years
Dog Breed
Labrador
Pet Problem(s)
  • Inflammation
Will Consume Product
Enjoyed
Pet Happiness
Just Right

He likes it!

Using this supplement to help keep my seven year-old golden lab in healthy condition.

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Pet Wellness Direct

We love hearing that—and your seven-year-old Golden Lab is absolutely handsome in his photo 🤍 It’s great that he enjoys taking the supplement, and even better that you’re using it proactively to help support his health and vitality at this stage of life. Preventative care makes such a difference, and it’s clear he’s in caring hands 🐾💛

Reviewed by Lisa Y.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Inflammation
  • Joint Pain
Will Consume Product
Enjoyed
Pet Happiness
Just Right

Great product

Ruby is a 12 yo Great Dane mix who has had elevated liver enzymes that kept getting higher with every visit. After taking Critical immune defense her lab work is coming down. She has been on it now for a year and we will continue to give it to her forever.

Lisa

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Pet Wellness Direct

Lisa, thank you for sharing Ruby’s story—she is such a beautiful 12-year-old Great Dane mix, and her photo is just lovely 🤍 We know how stressful rising liver enzymes can be, so it’s wonderful to hear that after a year on Critical Immune Defense, her lab work is finally coming down. Your dedication to Ruby’s long-term health truly shows, and we’re honored to be part of her journey 💙🐾

Reviewed by Brenda M.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Australian Shepherd
Pet Problem(s)
  • Inflammation
  • Stress
  • Tumor
Will Consume Product
Devoured
Pet Happiness
Just Right

This works

My Australian shepherd has been dealing with some unidentifiable immune /

issue since we lost his brother a year ago which has caused him to break out in sores and he lost most of his coat. He also developed a fatty tumor on his side. We have tried every natural supplement and immune booster over and over.

Since starting the Immune Defense, he now has no new sores breaking out and he has patches of his coat, and dark undercoat slowly growing back in. The fatty tumor has also shrunk in size. It has only been a few months, but this is working when nothing else has. I am very happy and will continue using this product. Don’t waste your money on anything else.

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Pet Wellness Direct

Thank you for sharing — it’s so encouraging to hear your Australian Shepherd is finally seeing relief. 🐾 The return of his coat, no new sores, and a shrinking fatty tumor after trying so many options is truly meaningful. We’re glad Critical Immune Defense is helping when nothing else did. ❤️

Reviewed by TONYA A. C.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
7 - 10 Years
Dog Breed
German Shepherd
Pet Problem(s)
  • Tumor
  • Joint Pain
  • Inflammation
Will Consume Product
Enjoyed
Pet Happiness
Tail Wagging

Critical immune defense

I truly love love this product. I have five German shepherds and just wanting to keep them all healthy. One of my fur babies is 13 years old and since giving her this, I really saw a difference. The only downfall for me is I may not be able to get it anymore because it’s just so expensive, and with five German shepherds I’m supposed to give six scoops per day for each of my five German shepherds. This is that’s not the Company’s fault that I have a lot of dogs. I thought about just buying it and giving it to only my 13-year-old girl, but then the guilt hits me and I can’t play favorites. I want to keep them all healthy not give it to them when they get sick or old. But again I highly recommend this ….so if you have a little dog, medium dog, even a big dog and it’s only one large dog or two ……please try this you will thank me.

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Pet Wellness Direct

Thank you for sharing your pup's updates — it’s clear how much you love and care for your five German Shepherds. 🐾 Seeing a difference in your 13-year-old is wonderful, and we truly understand the challenge of supporting a large pack. Your heartfelt recommendation means a lot to us. ❤️

Reviewed by Annette B.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5
Pet Age
10+ Years
Dog Breed
Labrador
Pet Problem(s)
  • Joint Pain
  • Tumor
  • Limp
Will Consume Product
Devoured
Pet Happiness
Tail Wagging

Cadburys lump

Been using for about 6 months. Cadbury is a 12 year old Lab. Has been much more comfortable and active. His lump is not smaller but also has not grown in size. Started my 8 year old lab on it now to help his immune system system.

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Pet Wellness Direct

Thank you for sharing Cadbury’s update — he sounds like he’s doing really well. 🐾 It’s great to hear that at 12 years old, he’s more comfortable and active, and that his lump has remained stable after six months. That kind of consistency can mean a lot. We’re also glad you’ve started your 8-year-old Lab on it for immune support — we truly appreciate your trust and care for both of them. ❤️

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