Critical Immune Defense

Rated 4.7 out of 5
Based on 967 reviews
Sale price$65.00 USD
Size: 1 Bottle
Free shipping on subscriptions & orders $75 or more.

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Your Pet's Immune System Is the Key to Its Health

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet. Let’s face it. Your dog and cat lives in a world filled with contamination. They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants. The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful.

    Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health. Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

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    50%

    Cancer Rates are skyrocketing

    More dogs and cats are being diagnosed with cancer than ever before.

    According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    “One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

    Pet Owners CAN Make A Difference

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

    Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and mmunomodulatory properties that may help fight cancer and certain other diseases.”

    - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    More dogs and cats are being diagnosed with cancer than ever before.

    According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    “One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

    Pet Owners CAN Make A Difference

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

    Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and mmunomodulatory properties that may help fight cancer and certain other diseases.”

    - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    The doctors agree

    Dr. Frank Markland

    Professor of Biochemistry and Molecular Medicine at the University of Southern California Keck School of Medicine.

    Dr. Shawn Messonnier

    Veterinary Medicine and author of "The Natural Vet's Guide to Preventing and Treating Cancer in Dogs"

    Dr. Jennifer Edwards

    Ponemah Veterinary Hospital

    Where you have seen us

    Critical Immune Defense

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    The all-natural solution. Trusted by veterinarians.

    Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

    Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Frequently Asked Questions

    Happy Customer Reviews

    average rating 4.7 out of 5
    Based on 967 reviews
    • 5 Stars
      800 Reviews
    • 4 Stars
      100 Reviews
    • 3 Stars
      48 Reviews
    • 2 Stars
      7 Reviews
    • 1 Star
      12 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    967 Reviews
    Reviewed by Linda D.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Low Energy

    Happy pups

    We have a 10-year-old rescue and a three and a2 year-old golden retriever and they are both given a scoop of Critical Immune defense every Morning as a topper on their food, our 10-year-old can run with the best of them and I’m hoping that the critical immune defense will help deter health issues for our golden

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Linda, We're so happy to hear about your furry family's vitality with Critical Immune Defense! The pictures of your happy pups are beautiful! 🐾❤️ Here's to many more years of health and happiness for your beloved companions! 😊

    Reviewed by Joseph V.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    3 - 5 Years
    Pet Problem(s)
    • Tumor
    • Joint Pain

    Helps with a lot of things

    Our dog doesn't cough anymore and I was able to skip his allergy meds last fall for the first time. The reason I purchased it was our dog has an irregular heartbeat and they didn't find a reason and said it might be cancer somewhere, now his heartbeat is normal.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Joseph, We're happy to hear about the positive changes with Critical Immune Defense! From no more coughing to a normalized heartbeat, it's incredible progress. The provided picture and video of your furry friend must be adorable, and it's evident how much he's thriving. 🐾❤️ Here's to continued health and happiness for your beloved pup! 😊

    Reviewed by Holly H.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Cat Breed
    American Shorthair
    Pet Problem(s)
    • Cancer

    Follow up on my cat Punkin!

    After having my cat Punkin who is suffering from liver tumors and a galloping heart, I’ve noticed a definite difference in his quality of life, since being on this product. His appetite is much better and he acts interested in everything more, and acts like his old happier self! I would definitely recommend this product to people and their precious pets if they are not doing well. I have definitely noticed a difference! Thank you Pet Wellness Direct and Immune Defence for a great product that is noticeably helping my pet! I highly recommend this for anyone’s pet that isn’t doing well..I made this video of Punkin outside in late April to show how happy he is, and is still with me! Yayyyyy!! ❤️😻❤️

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated -2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Holly, Your update on Punkin is heartwarming! It's amazing to see how he's thriving with Critical Immune Defense. The video of him outside is precious—he's clearly loving life! 🐾❤️ Keep up the great work, and here's to many more joyful moments with Punkin! 😊

    Reviewed by Ruth K.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Labrador
    Pet Problem(s)
    • Hip Pain
    • Joint Pain
    • Inflammation
    • Bad Breath

    Holly's 2nd Wind

    Holly is a 12yr old Chocolate Labrador Retriever. Last August 2023 we paid the money to save Holly's life. She had Laryngeal Paralysis which Holly couldn't breath. She would have a sound of a, "Roar". After surgery, we learned how close we were to actually losing our girl. Holly's Left side of the airway way completely closed, and her Right side of her airway would only work at 20%. Also, Holly has Hip/Joint/Inflammation issues; not to mention Bad Breath.

    When Holly started trying Critical Immune Defense the, "Mushroom Craze" seemed like it has taken off in ALL different products. We were on another product called Buddy Guard that claimed to take away the lumps. The only thing about this product is that it has more mushrooms in its ingredients, and it really made Holly very sleepy. So, Holly was only on it for one week until she switched over to Critical Immune Defense.

    The main reason why we wanted to try this product is because Holly has many Lipoma's. Plus, she has a Adenoma (hard) behind her left ear, and a Cyst (hard)on her lower back towards her butt. All of these are Benign thank goodness!!

    Critical Immune Defense gave Holly a lot of energy. I was very happy to see this old gal try to run out in the yard with her 2 yr old German Shepherd sister who gives her a run for her money. Unfortunately, my husband, Vet and I haven't seen any lumps go away; in fact, Holly gained another Lipoma!!

    Would I recommend this product? Yes, if your dog needed Vitamins. I plan on keeping…

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    Effectiveness
    Rated -2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Ruth,
    Your review of Holly's journey is truly heartwarming! 🐾 Despite her hip and joint issues, it's amazing to see her resilience and progress since her surgery last August. We're thrilled to hear that Critical Immune Defense has given her more energy to keep up with her playful sister! 🌟 While the lumps may not have disappeared as quickly as hoped, Holly's overall health improvement is fantastic. Your dedication to her well-being is inspiring. Here's to more joyful adventures together! 🌺🐶

    Reviewed by Kathleen A.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    5 - 7 Years
    Dog Breed
    Pitbull Terrier
    Pet Problem(s)
    • Tumor
    • Stress
    • Inflammation

    Critical Immune Defense

    Penny Lane has suffered from mast cell tumors and fatty cysts. Since using the critical immune defense she has not experienced any new tumos, lumps or bumps. Her energy is good and her health is great. I will continue to use this product everyday.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Kathleen! 🐾 We're thrilled to hear about Penny Lane's amazing progress with our Critical Immune Defense supplement! It's wonderful that she hasn't experienced any new tumors or lumps since starting the regimen. The picture you shared of her is adorable! 🌟🐾