Critical Immune Defense

Rated 4.7 out of 5
Based on 892 reviews
Sale price$65.00 USD
Size: 1 Bottle
Free shipping on subscriptions & orders $75 or more.

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Your Pet's Immune System Is the Key to Its Health

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet. Let’s face it. Your dog and cat lives in a world filled with contamination. They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants. The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful.

    Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health. Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

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    50%

    Cancer Rates are skyrocketing

    More dogs and cats are being diagnosed with cancer than ever before.

    According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    “One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

    Pet Owners CAN Make A Difference

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

    Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and mmunomodulatory properties that may help fight cancer and certain other diseases.”

    - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    More dogs and cats are being diagnosed with cancer than ever before.

    According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    “One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

    Pet Owners CAN Make A Difference

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.”

    Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and mmunomodulatory properties that may help fight cancer and certain other diseases.”

    - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    The doctors agree

    Dr. Frank Markland

    Professor of Biochemistry and Molecular Medicine at the University of Southern California Keck School of Medicine.

    Dr. Shawn Messonnier

    Veterinary Medicine and author of "The Natural Vet's Guide to Preventing and Treating Cancer in Dogs"

    Dr. Jennifer Edwards

    Ponemah Veterinary Hospital

    Where you have seen us

    Critical Immune Defense

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    The all-natural solution. Trusted by veterinarians.

    Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

    Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Frequently Asked Questions

    Happy Customer Reviews

    average rating 4.7 out of 5
    Based on 892 reviews
    • 5 Stars
      737 Reviews
    • 4 Stars
      93 Reviews
    • 3 Stars
      43 Reviews
    • 2 Stars
      7 Reviews
    • 1 Star
      12 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Customer photos and videos
    892 Reviews
    Reviewed by Maureen J.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Overweight
    • Tumor
    • Joint Pain
    • Cancer

    Great product

    My dog loves it and her lumps have almost disappeared. So happy with it.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Maureen, thank you for sharing your pup's wonderful progress with us! We're thrilled to hear about her improved health and how much she's enjoying the Critical Immune Defense. 🐾 🐶💕

    Reviewed by Jamie C.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Jack Russell
    Pet Problem(s)
    • Tumor
    • Cancer
    • Low Energy
    • Stress

    My dog has prostate cancer

    My little boy has had a rapidly growing prostate tumor since October 2023. We have been on and off heavy duty antibiotics for reoccurring urinary tract infections. He has been on a cancer, patient medication to help control the growth of the tumor as well as pain. We started this product a month ago, and since starting this product, he has gone back to being puppy like. His appetite has greatly increased. Honestly better than it has been in years. I thought we would have to say goodbye very soon, and gave this product a try as a last ditch effort. It has honestly given him his life back. He was very depressed, now he is happy and energetic. I hope that it slows the tumor down enough to give us many more months, if not years.

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Jamie, thank you for sharing your Jack Russell's journey with prostate cancer. We're so happy to hear how Critical Immune Defense has brought back his puppy-like energy and hearty appetite, giving him a new lease on life. The transformation is truly inspiring, and we're honored to have played a part in his well-being. Here's to many more joyful moments together! 🐾

    Reviewed by Sheila N.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Tumor
    • Bad Breath

    .

    Our 12 year old puggle has been on this for more than 3 months . He runs around effortlessly. And his lymps and bumps have shrunk. Tho they have not gone away. At the least they have not gotten any bigger. Will continue the product.

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Sheila, thank you for sharing your positive experience with Critical Immune Defense! It's wonderful to hear about your 12-year-old puggle's improved energy and health progress. We're committed to supporting him on his journey to wellness. Keep up the great work! 🐾

    Reviewed by Julie M.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Chihuahua
    Pet Problem(s)
    • Tumor
    • Cancer

    This is a miracle. Thank God and thank Pet Wellness!

    My 10 yr old chihuahua has a mast cyst tumor on her back leg. Vet found it late last year. They wanted to cut her leg off. No way. I started giving her the critical immune defense in December. The tumor has reduced in size- it’s 1/3 the size it was. In two months’ time. Before and after pictures below. This stuff is a Godsend.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Julie, Thank you for sharing such an amazing progress story about your chihuahua! It's heartening to see the positive impact of Pet Wellness Critical Immune Defense on reducing her mast cyst tumor. 🙌 Your dedication to her health is truly inspiring. Wishing your sweet pup continued well-being and happiness!

    Reviewed by Kelly R.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Collie
    Pet Problem(s)
    • Inflammation
    • Bad Breath

    Great results acheived

    I have had great results w/my CH. Smooth Collie bitch Evie, GCHB Cyndella's ICandy. Evie will be 11 in May and was in pretty good health, but was diagnosed w/Urinary Incontinence last year. She has been taking prescribed medicine DES, but wanted to find something so I could lower the dose. I have been able to cut her back to almost just 1 a week. She does get blood work every 6 months, but I really feel this has helped and also increased her energy level. Thanks for your product discovered on Facebook.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    Pet Happiness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Tail Wagging
    Will Eat Product
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
    Was this helpful?

    Pet Wellness Direct

    Hi Kelly, Thank you for sharing Evie's amazing progress with us! It's heartening to hear how our product has positively impacted her health, especially in managing her urinary incontinence. 🐾 Your trust means the world to us, and we're here to support Evie's well-being every step of the way!