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Critical Immune Defense
Critical Immune Defense
Critical Immune Defense
Critical Immune Defense
Critical Immune Defense
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Critical Immune Defense

Rated 4.7 out of 5
Based on 204 reviews
Regular price
$59.95
Sale price
$59.95
Regular price
$79.95
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  • Boosts the Immune System
  • Reduces Inflammation
  • Promotes Normal Cell Growth
  • Money Back Guarantee

MSRP $79.95
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1 Bottle $59.95

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1 Bottle $56.95

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MSRP $239.85
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3 Bottles $159.95

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3 Bottles $151.95

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MSRP $479.70
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6 Bottles $299.95

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6 Bottles $284.95

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Strengthens the immune system

Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

Protects against diseases

Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

Promotes normal cell growth

Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

Works with prescription medications

Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

Can extend your pet's life

Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

Backed by science

Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

Your Pet's Immune System Is the Key to Its Health

In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet. Let’s face it. Your dog and cat lives in a world filled with contamination. They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants. The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful.

Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health. Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

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Cancer Rates Are Skyrocketing

More dogs and cats are being diagnosed with cancer than ever before. According to the Veterinary Cancer Society, almost 50% of all dogs and 32% of all cats over the age of 10 will develop cancer. Younger pets are also increasingly at risk. “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.” - Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

“One of the things that can be helpful is supporting your pet’s immune system with antioxidants to help its body to use its own natural defenses against disease. Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards. According to Dr. Edwards, another way to protect your pets is with all-natural health supplements.

Pet Owners CAN Make A Difference

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins.” – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas. “Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.” - Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

THE DOCTORS AGREE.

Dr. Frank Markland

Professor of Biochemistry and Molecular Medicine at the University of Southern California Keck School of Medicine.

Dr. Shawn Messonnier

Veterinary Medicine and author of "The Natural Vet's Guide to Preventing and Treating Cancer in Dogs"

Dr. Jennifer Edwards

Ponemah Veterinary Hospital

Where you have seen us

Key Ingredients

Turkey Tail Mushroom

This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

Reishi Mushroom

This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

Shiitake Mushroom

According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

Maitake Mushroom

Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

White Turmeric Root Extract

Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and liver damage.

Critical Immune Defense Has MORE Active Ingredients Than The Others

The all-natural solution. Trusted by veterinarians.

Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

Made in the USA to the highest quality standards



VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

Frequently Asked Questions

VetSmart Formulas were originally designed for veterinarians. This means they deliver the clinical-strength quality and efficacy veterinarians demand in products they provide and recommend. They are wheat-free and contain no artificial colors or flavors. Moreover, it can be used along with most products and prescription medications available for pet consumption.

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Thousands of dogs in all sizes and weights continue to benefit every month from VetSmart Formulas to boost their immune system and overall health.
If your dog has a situation similar to the other dogs you may have read about in our reviews, then this product may likely help your dog too.

Critical Immune defense helps protect your pet against:

  • Abnormal cell growth
  • Harmful pathogens such as bacteria, viruses, fungi, and parasites
  • Inflammation
  • Infection
  • Cardiovascular disease
  • Hormone imbalance
  • High blood pressure
  • Arthritis
  • Liver damage

… and more.

That being said, every dog is unique and unfortunately there are some dogs that have problems this formula cannot solve. This is exactly why we offer a 30 day risk-free money back guarantee.

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Great news... not only do we offer a 30-day money back guarantee, we also provide Free Shipping on Domestic Orders Over $100.

If you’re trying this product for the first time and only want to start with 1 bottle, we only charge you our cost of $5.95 for postage and handling. (US Domestic)

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When your pet’s immune system is functioning at an optimal level, it will naturally balance the “normal activity” that should take place. The immune system fights infections, and removes harmful viruses and bacteria, and it slows the aging process. A strong immune system will also boost Natural Killer (NK) and T-Helper cell production that helps prevent and slow cancer cell reproduction. So, a strong and healthy immune system will keep your pet safe and healthy!

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The time to start any preventative action is before your pet has an issue. As dogs and cats age, their immune systems are not as strong, and they are more susceptible to diseases. A weak immune system in dogs and cats can cause a variety of diseases such as infections, diabetes, osteoarthritis and cancers. Be a proactive pet owner and start boosting your pet’s immune system while they are younger and BEFORE they have an issue.

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Not likely. However, if you know (or think) that your pet has a sensitive stomach ease into the product slowly. Start with 1/3 or 1/2 the recommended dose and work your way up to full dose over a 1-2 week period. If you notice any issues, simply stop using the product or cut back to find the level that works for your pet.

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Yes. Our product is all-natural and designed to be taken with chemotherapy medications. It will help boost their immune system that might be compromised by the chemotherapy medications. If your pet is being treated for any serious medical condition, we always suggest that you discuss the use of any supplements with your veterinarian. You can simply bring the bottle to them during a visit or take a photo of the label and share it with your vet.

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Yes. Our product is all-natural and designed to be taken with prescription medications. It will help boost their immune system that might be compromised by the medications. Again, we always suggest that you discuss the use of any supplements with your veterinarian. You can simply bring the bottle to them during a visit or take a photo of the label and share it with your vet.

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No pet is too old to start using an all-natural product that will help them live a better and longer life! It’s similar to someone who starts exercising at 80 years old. Every bit helps! Start now and you will help to prolong your pet’s lifespan!

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We can’t guarantee that, but what we do know is our product is very effective at boosting your pet’s immune system which helps fight all types of diseases such as cancers. The research on the ingredients in Critical Immune Defense is very extensive and Asian cultures have used these ingredients effectively for many centuries.

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Critical Immune Defense is very easy to give to your pet. It’s a powder that you simply sprinkle on their food. It has a natural hypo-allergenic chicken flavor that appeals to both dogs and cats, and most pets love the flavor. We offer a 30-day money back guarantee if they don’t like the taste.

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We agree. The numbers are frighteningly high! These statistics were published by the Veterinary Cancer Society. There is so much research and so many clinical studies on the percentages of dogs and cats that get cancer. You can Google it and see the various studies online.

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No, they are not. Turkey Tail Mushroom, also known as Coriolus Versicolor, is a common type of mushroom that has the shape and color of a turkey tail. What is unique about the Turkey Tail Mushrooms that we use in Critical Immune Defense is the mushrooms are harvested at a very young age when the polysaccharide K (PSK) and peptides are the most concentrated, and these active compounds boost the immune system. As a reference, polysaccharide K (PSK) is an approved mushroom product to treat cancer in Japan.

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Here’s a way to think about it. High blood pressure is known as the “silent killer.” That’s because people may have high blood pressure for many years and not notice it. However, because there are no visible signs does not mean nothing is happening in your body. The same is the case with boosting your pet’s immune system. You may notice that your pet is more lively or peppy, or you may not notice anything at all. Keep in mind that not seeing a visible result does not mean the product is not working.

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We love this question! Our product is one of the most powerful immune boosters for pets on the market. We have combined a blend of four mushrooms along with turmeric and vitamins to create what we feel is the absolute best immune booster for pets. Our ingredients are standardized to the highest potency and the product is veterinarian strength. We invite you to compare the labels and the ingredients in our product to any others on the market to see for yourself!

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Most mushrooms are very beneficial to humans and both cats and dogs, and less than 1% of mushrooms are harmful. The mushrooms that we use in Critical Immune Defense are “medicinal mushrooms” and they have been used to boost immune systems for centuries and are proven to be safe and effective for cats and dogs. For more than 30 years medicinal mushrooms have been approved as cancer treatments in Japan and China. More recently, the U.S. Food and Drug Administration (FDA) has approved clinical trials for Turkey Tail and other medicinal mushrooms.

We didn't discover turkey tail," says lead investigator Leanna J. Standish, PhD, ND, LAc, FABNO, Medical Director of the Bastyr Integrative Oncology Research Center. "It's been used in Asia for thousands and thousands of years, and it turns out to be a really potent immune therapy. The significance, I think, is that we're bringing a new medicine to cancer patients in the U.S."

Studies are being conducted at several U.S. research universities, including the University of Pennsylvania School of Veterinary Medicine to gather data on the cancer and tumor-fighting effects of mushrooms in dogs, and the development of transformative cancer therapy for pets.

Please do your own online research to learn more about the benefits of the mushrooms in our product and the research being conducted. It is quite amazing!

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average rating 4.7 out of 5
Based on 204 reviews
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    1 Review
95% of reviewers would recommend this product to a friend
Effectiveness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Subtle Changes, 0 is Noticeable Improvement and 2 is Night and Day Difference
Pet Happiness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Furious Tail Wagging
Will Eat Product
Rated 0 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
204 Reviews
Reviewed by Alisa K.
Verified Buyer
I recommend this product
Pet Age
5 - 7 Years
Dog Breed
American Bulldog
Pet Problem(s)
  • Tumor
Rated 5 out of 5
Review posted

No return of tumor!

After our mastiff had a grapefruit sized hemangiosarcoma removed from his leg (we adopted him from a rescue) we opted for this product over radiation and chemo. He has no reoccurrence and it’s been 2 years.

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Effectiveness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Subtle Changes, 0 is Noticeable Improvement and 2 is Night and Day Difference
Pet Happiness
Rated 1 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Furious Tail Wagging
Will Eat Product
Rated 1 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?
Reviewed by KATHLEEN S.
Verified Buyer
I recommend this product
Pet Age
10+ Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Joint Pain
  • Hip Pain
Rated 5 out of 5
Review posted

Feel great doing whatever is possible for my dogs

At first they did not like it sprinkled on their food but I am mixing it with bone broth, and pouring it on their dry food, adding vegetables as well as their usual freeze-dried dog food.

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Effectiveness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Subtle Changes, 0 is Noticeable Improvement and 2 is Night and Day Difference
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Furious Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?
Reviewed by Stephen G.
Verified Buyer
I recommend this product
Pet Age
10+ Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Inflammation
  • Tumor
  • Joint Pain
Rated 5 out of 5
Review posted

Hiker Dog Kennels

It works on my dogs. There are seven 10 year olds left, of a litter of nine. Three have had cancer surgery, and are taking it in the morning and evening. Turkey Tail seems to give boosting power to the remedies they take.

One has outlived his date with death. With Wheatgrass Therapy, along with Critical Immune Defense, the difference is notable. There are a list of other herbs, and even a steroid he takes, but I make sure he gets two scoops of Critical Immune Defense in the morning food, and also in his evening meal. Don’t want to run out of it at this point, because it now becomes routine treatment. Thank you for making a pure product capable of helping a dog’s immune system fight back…

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Effectiveness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Subtle Changes, 0 is Noticeable Improvement and 2 is Night and Day Difference
Pet Happiness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Furious Tail Wagging
Will Eat Product
Rated 0 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?
Reviewed by Katrina O.
Verified Buyer
I recommend this product
Pet Age
10+ Years
Dog Breed
Mixed Breed
Pet Problem(s)
  • Tumor
Rated 4 out of 5
Review posted

No new metastasis!

So far so good. I may not have seen any visible changes, but I didn't expect to as Beorn has always had a huge appetite, and his advanced arthritis keeps him pretty slow BUT it's been almost 3 months since we had to remove one of his lymph nodes due to cancer metastasis from oral melanoma, and his xrays this week came back clean! No new spread!

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Effectiveness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Subtle Changes, 0 is Noticeable Improvement and 2 is Night and Day Difference
Pet Happiness
Rated 0 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Furious Tail Wagging
Will Eat Product
Rated 0 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?
Reviewed by Fred O.
Verified Buyer
I recommend this product
Pet Age
10+ Years
Dog Breed
Cocker Spaniel
Pet Problem(s)
  • Inflammation
Rated 5 out of 5
Review posted

Stopped scratching

My little guy seemed to be allergic to everything and had skin lesions and constant itching.. After a week His itching has stopped and he is so much happier.

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Effectiveness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Subtle Changes, 0 is Noticeable Improvement and 2 is Night and Day Difference
Pet Happiness
Rated 2 on a scale of minus 2 to 2, where minus 2 is Bummed, 0 is Just Right and 2 is Furious Tail Wagging
Will Eat Product
Rated 2 on a scale of minus 2 to 2, where minus 2 is Nibbled, 0 is Enjoyed and 2 is Devoured
Was this helpful?