FIGHT VIRUSES, DISEASES, AND CANCERS.

Critical Immune Defense for Dogs

Rated 4.7 out of 5
Based on 1615 reviews
Sale price$65.00 USD
Size: Small | 70 Scoops
Free shipping on all US mainland orders

There simply isn't another product of this quality and strength available on the market, with THOUSANDS of testimonials about the results!

Critical Immune Defense is a safe, all-natural immune booster that can add years to the life of your dog.
Made in the USA.

Just sprinkle a small amount of powder on your dog's food. It tastes great, even for the most finicky of pets!

✔︎ Boosts immune system

✔︎ Reduces inflammation

✔︎ Promotes normal cell growth

✔︎ Protects against toxins in food, water & environment

✔︎ Supports long-term health in dogs and cats

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"I've lost two golden retrievers to cancer, so I've been doing a ton of research since I got my newest puppy. I want to give him the best chance of living a long and healthy life and Critical Immune Defense is a key part to that equation. He likes it and I believe in being proactive! So glad I found this company!"

- Audrey (Verified Customer)

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"30 days ago I went to a cancer specialist who told me that my dog’s prognosis was not very good and he would eventually get lumps and tumors all over his body. I left very depressed.
I found your product online by a miracle, and I started giving it to him. I don't know what it’s doing, but all older cancer tumors are gone and it seems to have eliminated the new tumors as well. I've been giving the VetSmart product twice a day for approximately 30 days. I'm just so grateful and so thankful that it works so well. He is looking really, really good. Thank you so much! I need to order more soon.”

- Paul (Verified Customer)

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Featured on

Your pet's immune system is the key to its health! Here's why:

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers. In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it: your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive! Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

Your pet's immune system is the key to its health! Here's why:

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers. In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it: your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive! Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

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"My female pitbull was diagnosed with lymphoma back in 2020. We did chemo for 2 years. During this time, I found the product and started using it on all my dogs, even healthy ones.

We are now in almost 4 years later, and my girl Haven has been in remission for almost 2 years. I only give the product in the dinner feedings. I believe it saved her."

- Diane (Verified Customer)

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"Sienna is 13 years old and is on two of your products. She been on this for several weeks and noticing a difference in enjoying the stairs again. Thank you for both! ❤️❤️❤️
Critical Immune Defense, has made a huge difference with a lump on her shoulder! Sienna is taking two of your products Critical Immune Defense, for a lump on her shoulder which has shrunk, to half its size after finishing first container, working on
Papilloma virus warts and skin tags...have two containers to go.
Sienna started having issues using the steps. I started her on your Hip+Joint product and within 10 days, no longer any issues. Sienna will be 14 this year. Loving these products 🙏🏻🤞🏻 in time Critical Immune Defense will help with the virus...."

- Gloria (Verified Customer)

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52%

CANCER RATES ARE SKYROCKETING

THE DOCTORS AGREE

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

More dogs and cats are being diagnosed with cancer than ever before. 

“Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

Turkey Tail Mushroom

This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

✔︎ Delivers significant amounts of tumor-fighting Polysaccharopeptides (PSPs)

✔︎ Approved by the United States Food & Drug Administration for use in treating prostate and breast cancer in humans

✔︎ Proven to delay the growth of cancerous tumors in pets and improve their survival rate

Reishi Mushroom

This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

✔︎ Contains beta-glucans that increase the immune system’s T-cell levels

✔︎ Lowers inflammatory responses caused by stress, poor diet, and other environmental factors

✔︎ Contains ganoderic acids that have been shown to lower cholesterol levels and blood pressure

Shiitake Mushrooms

According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

✔︎ Contains all 8 essential amino acids as well as linoleic acid, an essential fatty acid

✔︎ Used in Japan to treat heart disease, hepatitis, high blood pressure, and infectious diseases

Maitake Mushrooms

Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

✔︎ Contains beta-1, 6 glucan polysaccharide components that stimulate the immune system and reduce abnormal cell growth

✔︎ Used in Asia to help minimize the toxic effects of radiation and chemotherapy treatment

White Turmeric Root Extract

Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and liver damage.

Our proprietary extract is six times more bioavailable than standard turmeric root, which means it’s more effectively absorbed into your pet’s body and they need less of it to get the same effect. It’s also colorless and milder tasting, making it easier to handle -- and tastier for your pet! No more turmeric stains!

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"My dog is now 21 years old and this has helped so much. She is on her 3rd bottle, things were grown on face they are much smaller. She used to go to bathroom on herself, now she gets out of bed to go. She is close to 22, she eats at least 2 big meals a day! I know each day is a blessing with her! She is a Boston terrier and Rat terrier. this has helped tremendously! Thank you for giving her new time! Her eyes have also gotten much brighter too!"

- Gina (Verified Customer)

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Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

70 Scoops in a small bottle
210 scoops in a large bottle
10% Additional Saving

⭐️⭐️⭐️⭐️⭐️

"This product has been a blessing for our Ellie. Diagnosed with mast cell cancer given 1 year to live that was almost 4 yrs ago. She will be 12 in a few months we started her on this when she was 8 yr old. Still doing fantastic plays and acts like a puppy. Love this product.”

- Edie (Verified Customer)

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The All-Natural Solution. Trusted By Veterinarians.

Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

✔︎ No artificial colors

✔︎ No artificial flavors

✔︎ Wheat-free

Made in the USA to the highest quality standards.

VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs. Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved pet’s health.

Frequently Asked Questions

Still have questions?

Talk to us on Facebook Messenger

Or give us a call at 888-212-8400 Mon-Fri 9:00 to 5:00 PST

Returns | 30-Day Money Back | Ingredients

average rating 4.7 out of 5
Based on 95 reviews
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92% of reviewers would recommend this product to a friend
Customer photos and videos
95 Reviews
Reviewed by Audrey L.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5

Blossom Belle's health is improving

Each time she goes to have her blood platelet count taken, the numbers go down and her doctor reduces her prescription drug. Also since being on the critical immune defense, she did not have to have her pancreas aspirated. I believe in using vitamin therapy. Below is a picture of her dancing for her treats. She is years old now.

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Pet Wellness Direct

Thank you for sharing Blossom Belle’s progress! 💕 It’s so encouraging to hear her platelet counts are improving, her medications being reduced, and that she hasn’t needed a pancreas aspiration since starting Critical Immune Defense 🌟. Her photo dancing for treats is absolutely precious—what a joyful, resilient girl!

Reviewed by Michelle B.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5

USING CID

My dog Willow, a 11 year old Springer Spaniel LOVES IT..over her food. MY blind 18 year old Maltese (who I rescued the day they were going to kill him back in 2016) is really picky..and will not eat it with food. I syringe Colby all of his meds, so I do that with CID with no problem. I DO NOTICE GREAT DIFFERENCES IN BOTH..I ORDERED IT AGAIN!! I also ordered the JOINT chews..Will let you know how that works too!..Here are 2 pics..my video is too big.. I have rescued and KEPT over 65 dogs..4 pot belly pigs..cats..some birds. When I married in Dec 2020 I had 16 dogs..and Colby is my last one still not up in Heaven. Willow came with my husband...I really really wish I had known about your products all those years ago. Thank you for providing them.

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Pet Wellness Direct

Wow, thank you for sharing such an inspiring story, Michelle! 💕 Willow sounds like she’s thriving at 11, and it’s incredible to hear Colby—at 18!—is doing well with CID too. 🌟 The love and dedication you’ve given to over 65 rescues (plus pigs, cats, and birds!) is truly remarkable, and Colby and Willow are so lucky to have you. Their photos are precious, and we’re grateful you’ve trusted our products to be part of their journey—we can’t wait to hear how the Joint Chews work out!

Reviewed by Sandy M.
Verified Buyer
Review posted
I recommend this product
Rated 4 out of 5

Gives him more energy

I feel like he has more energy but I was hoping his lipomas would get smaller.

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Pet Wellness Direct

Hi Sandy, thank you for sharing your pups update. 💕 We’re glad to hear your pup has more energy—that’s always wonderful to see 🌟. We truly appreciate your dedication in supporting his health.

Reviewed by Cheryl A.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5

Sophies so much more active and the bump on chest firmed then disappeared

I got it mostly for my 14Y terrier mix. She was quieter, going under bed when it was time to be fed. Shes now again more active looking for mischief and enjoying walks. She and Zeke you newest rescue are back to doing zoomies at moments notice. Give it to my cats as well in smaller amnts as preventative. They are 6 and 7. The grey and white Kizzy baby is more tolerant of the boys antics.

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Pet Wellness Direct

Hi Cheryl, thank you for sharing your story. 💚 It’s wonderful to hear that 14-year-old Sophie is more active again, with her chest bump gone, and that she’s back to enjoying walks and even zoomies with Zeke. Your photos are adorable—you can see the spark in their eyes 🐾. We love that Kizzy and the cats are benefiting too, and it’s clear all your furry family is thriving with your care!

Reviewed by Dmitri A.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5

Great product

My dog has stage 5 cancer i thought my time with her would be a lot shorter. A friend told me about your product and I said I would try it. I have been using it for a couple of months and my girl is still alive I believe that your product is helping her.

Thank you

Dmitri

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Pet Wellness Direct

Thank you for sharing your girl’s journey with us, Dmitri 💚. We’re so touched to hear that, even with stage 5 cancer, she’s still with you and fighting strong after a couple of months on Critical Immune Defense. Her photo is beautiful—you can see the love and resilience shining through 🐾. We’re honored to be a part of her care and wish you both many more cherished moments together.