FIGHT VIRUSES, DISEASES, AND CANCERS.

Critical Immune Defense for Dogs

Sale price$65.00 USD
Size: Small | 70 Scoops
Free shipping on all US mainland orders

There simply isn't another product of this quality and strength available on the market, with THOUSANDS of testimonials about the results!

Critical Immune Defense is a safe, all-natural immune booster that can add years to the life of your dog.
Made in the USA.

Just sprinkle a small amount of powder on your dog's food. It tastes great, even for the most finicky of pets!

✔︎ Boosts immune system

✔︎ Reduces inflammation

✔︎ Promotes normal cell growth

✔︎ Protects against toxins in food, water & environment

✔︎ Supports long-term health in dogs and cats

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"I've lost two golden retrievers to cancer, so I've been doing a ton of research since I got my newest puppy. I want to give him the best chance of living a long and healthy life and Critical Immune Defense is a key part to that equation. He likes it and I believe in being proactive! So glad I found this company!"

- Audrey (Verified Customer)

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"30 days ago I went to a cancer specialist who told me that my dog’s prognosis was not very good and he would eventually get lumps and tumors all over his body. I left very depressed.
I found your product online by a miracle, and I started giving it to him. I don't know what it’s doing, but all older cancer tumors are gone and it seems to have eliminated the new tumors as well. I've been giving the VetSmart product twice a day for approximately 30 days. I'm just so grateful and so thankful that it works so well. He is looking really, really good. Thank you so much! I need to order more soon.”

- Paul (Verified Customer)

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Featured on

Your pet's immune system is the key to its health! Here's why:

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers. In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it: your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive! Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

Your pet's immune system is the key to its health! Here's why:

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers. In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

Let’s face it: your pet lives in a world filled with contamination.

They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

What do you do?

You need to put your pet’s immune system in overdrive! Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

"The immune system acts like a nonstop housekeeper", describes Dr. Donna Raditic, an American College of Veterinary Nutrition (ACVN) diplomate in Athens, Georgia.

It identifies potentially harmful pathogens like bacteria, viruses, fungi, and parasites, then works to eliminate them before they can do harm.

And a pet's immune system monitors cells to ensure they’re working properly.

“When other cells are aging or functioning abnormally—such as a cancer cell reproducing too rapidly—the immune system attempts to step in and maintain proper physiological function and balance,” Dr. Raditic explains.

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"My female pitbull was diagnosed with lymphoma back in 2020. We did chemo for 2 years. During this time, I found the product and started using it on all my dogs, even healthy ones.

We are now in almost 4 years later, and my girl Haven has been in remission for almost 2 years. I only give the product in the dinner feedings. I believe it saved her."

- Diane (Verified Customer)

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"Sienna is 13 years old and is on two of your products. She been on this for several weeks and noticing a difference in enjoying the stairs again. Thank you for both! ❤️❤️❤️
Critical Immune Defense, has made a huge difference with a lump on her shoulder! Sienna is taking two of your products Critical Immune Defense, for a lump on her shoulder which has shrunk, to half its size after finishing first container, working on
Papilloma virus warts and skin tags...have two containers to go.
Sienna started having issues using the steps. I started her on your Hip+Joint product and within 10 days, no longer any issues. Sienna will be 14 this year. Loving these products 🙏🏻🤞🏻 in time Critical Immune Defense will help with the virus...."

- Gloria (Verified Customer)

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52%

CANCER RATES ARE SKYROCKETING

THE DOCTORS AGREE

Mushrooms = Anticancer Activity

“As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

Pet owners CAN make a difference.

“It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

– Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

More dogs and cats are being diagnosed with cancer than ever before. 

“Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

“Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

Turkey Tail Mushroom

This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

✔︎ Delivers significant amounts of tumor-fighting Polysaccharopeptides (PSPs)

✔︎ Approved by the United States Food & Drug Administration for use in treating prostate and breast cancer in humans

✔︎ Proven to delay the growth of cancerous tumors in pets and improve their survival rate

Reishi Mushroom

This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

✔︎ Contains beta-glucans that increase the immune system’s T-cell levels

✔︎ Lowers inflammatory responses caused by stress, poor diet, and other environmental factors

✔︎ Contains ganoderic acids that have been shown to lower cholesterol levels and blood pressure

Shiitake Mushrooms

According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

✔︎ Contains all 8 essential amino acids as well as linoleic acid, an essential fatty acid

✔︎ Used in Japan to treat heart disease, hepatitis, high blood pressure, and infectious diseases

Maitake Mushrooms

Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

✔︎ Contains beta-1, 6 glucan polysaccharide components that stimulate the immune system and reduce abnormal cell growth

✔︎ Used in Asia to help minimize the toxic effects of radiation and chemotherapy treatment

White Turmeric Root Extract

Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and liver damage.

Our proprietary extract is six times more bioavailable than standard turmeric root, which means it’s more effectively absorbed into your pet’s body and they need less of it to get the same effect. It’s also colorless and milder tasting, making it easier to handle -- and tastier for your pet! No more turmeric stains!

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"My dog is now 21 years old and this has helped so much. She is on her 3rd bottle, things were grown on face they are much smaller. She used to go to bathroom on herself, now she gets out of bed to go. She is close to 22, she eats at least 2 big meals a day! I know each day is a blessing with her! She is a Boston terrier and Rat terrier. this has helped tremendously! Thank you for giving her new time! Her eyes have also gotten much brighter too!"

- Gina (Verified Customer)

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Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

It’s your job to feed and nourish it, and make sure it operates at optimal levels to fight disease and cancers.
Order now

Not only is it easy to use (just sprinkle it over your pet’s food), but also your pet will love the taste!

70 Scoops in a small bottle
210 scoops in a large bottle
10% Additional Saving

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"This product has been a blessing for our Ellie. Diagnosed with mast cell cancer given 1 year to live that was almost 4 yrs ago. She will be 12 in a few months we started her on this when she was 8 yr old. Still doing fantastic plays and acts like a puppy. Love this product.”

- Edie (Verified Customer)

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The All-Natural Solution. Trusted By Veterinarians.

Originally designed for veterinarians, VetSmart Formulas delivers the clinical-strength, quality and efficacy veterinarians demand of solutions they provide and recommend.

Critical Immune Defense is 100% safe to use, has NO side effects, and can be used in conjunction with chemotherapy, steroid treatments and other medications.

✔︎ No artificial colors

✔︎ No artificial flavors

✔︎ Wheat-free

Made in the USA to the highest quality standards.

VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs. Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved pet’s health.

Frequently Asked Questions

Still have questions?

Talk to us on Facebook Messenger

Or give us a call at 888-212-8400 Mon-Fri 9:00 to 5:00 PST

Returns | 30-Day Money Back | Ingredients

average rating 4.7 out of 5
Based on 111 reviews
  • 5 Stars
    88 Reviews
  • 4 Stars
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  • 3 Stars
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  • 1 Star
    1 Review
92% of reviewers would recommend this product to a friend
Customer photos and videos
111 Reviews
Reviewed by Starr M.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5

Critical Defense

Suzy Cruse my 6 year old German Shepherd Rescue had terrible breath? It would knock over a truck driver? I started giving her Critical Defense and with in a week it was gone! Great product!

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Pet Wellness Direct

Thank you so much for sharing Suzy’s story! 💕 We’re so happy to hear your 6-year-old German Shepherd rescue is doing so well — and that her breath has completely turned around in just a week! 🐾 That’s incredible progress, and it’s wonderful to know Critical Immune Defense is helping her feel (and smell!) her best!

Reviewed by linda d.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5

Extended life and energy for our sweet boy❤️

Our 5 yr old black lab was diagnosed with osteosarcoma March 13 and we were told he probably wouldn’t make it two months and it was likely in his lungs and amputation was not a viable option. While researching I came across an add for critical immune support. Out of pure desperation I purchased. It online. It has been almost 8 months. He was doing so well with the exception of the bone tumor site, we decided to move forward with amputation. Blood work came back excellent and lung xrays are completely clear. He has recovered from the amputation and is running and playing with our other lab. The vet warns us we should not consider him cured as it may show up in another site but our boy is happy, shiny and living a good life for however long he does live. We will definately continue the critical immune support as we truly believe it has been a game changer for him.

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Pet Wellness Direct

Thank you so much for sharing your sweet boy’s incredible story. ❤️ We’re truly amazed by his strength and resilience — eight months later, running and playing after amputation is such a gift. Your love and care have clearly made all the difference, and we’re so happy to hear his blood work and lungs look great. 🐾 He looks so happy and radiant in his photo, and we’re honored that Critical Immune Defense has been part of his journey.

Reviewed by Robert X. H. J.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5

Critical Immune defense for dogs

Axel and Cooper have been on this for two months now and have noticed a increase in their energy level

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Pet Wellness Direct

Thank you so much, Robert for sharing. 💕 We’re so happy to hear that Axel and Cooper are feeling more energetic after two months on Critical Immune Defense — they're adorable! 🐾 They sound like such a fun, lively pair, and it’s wonderful to know they’re thriving and full of life!

Reviewed by Paula V.
Verified Buyer
Review posted
I recommend this product
Rated 5 out of 5

Maggie’s journey

Maggie has been going thru a rough couple of months. A lump was found in March but Dr said samples taken were nothing. Well after watching an area grow to the size of a lemon we consulted with the university of Florida. Went to derm dept than got refered to soft tissue dept. it’s been 4 weeks of recovery and I do believe this supplement had been a big help in giving her energy and comfort and let’s not forget the two lumps on her neck can nit be found now after using this product for a month now. Resting in her paw t shirt today.

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Pet Wellness Direct

Thank you so much for sharing Maggie’s story!💕 She’s been through quite a journey, and it’s amazing to hear how much strength and comfort she’s found during recovery. The fact that her neck lumps are now gone and her energy is back is such wonderful news! 🐾 She looks absolutely adorable in her paw t-shirt, and it’s clear she’s surrounded by so much love and care. We’re so glad Critical Immune Defense has been part of her healing journey!

Reviewed by Carol
Verified Reviewer
Review posted
I recommend this product
Rated 5 out of 5

Daisy has a lump.

I found you some how. I was going to bring Daisy to the vet. She had a lump on her chest near her right leg. It was about 2 inches in diameter and soft. When I red the reviews for your Immune defense They sounded what I wanted to here, helping all these dogs with health issues. I'm almost done with the with the first bottle and her lump is starting to go away. So I just ordered another bottle today. I'm so glad I found you. Thank you!

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Pet Wellness Direct

Thank you so much, Carol! 💕 We’re so happy you found us and that Daisy is responding so well — that’s incredible news! It’s wonderful to hear her lump is already starting to go away after just one bottle. She looks so sweet and full of life in her photo, and it’s clear how much love and care you give her. 🐾 We’re thrilled to be part of Daisy’s healing journey and cheering her on every step of the way!