Critical Immune Defense

Sale price$65.00 USD
Size: 1 Bottle

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1488 reviews
    • 5 Stars
      1233 Reviews
    • 4 Stars
      149 Reviews
    • 3 Stars
      73 Reviews
    • 2 Stars
      9 Reviews
    • 1 Star
      24 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    1488 Reviews
    Reviewed by Faith P.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Groodle
    Pet Problem(s)
    • Tumor
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    Lump free

    We have been adding critical immune defense to Logan's food for over a year. He appears to be lump free. For reference, Logan had a mass removed in February of 2024. He is 9 years old

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Faith, thank you so much for sharing! Logan looks absolutely fantastic—his happy, healthy stance says it all 🐾. At 9 years old and over a year post-mass removal, it’s incredible to hear he’s staying lump free. We’re so thrilled Critical Immune Defense is helping him feel his best, and we’re honored to be part of his journey 💛.

    Reviewed by Dawn R.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    German Shepherd

    So far so good

    I just feel good giving her Critical Defense.

    She seems very bright and healthy and full of energy. We walked 5 long miles yesterday. She did great and would’ve done more. I was wiped out but she was full of energy….9 years old going on 2!!!

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Dawn, Thank you for sharing! Your girl sounds incredible—her photo captures her vibrant spirit perfectly! 🐾 At 9 years old and still powering through 5 miles with energy to spare, it’s clear she’s feeling amazing. We’re so happy Critical Defense is helping her stay bright, healthy, and full of life 💛.

    Reviewed by Robin G.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Inflammation
    • Tumor
    • Cancer
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Lily Approves!

    My 13 year old Lily is a fan! She has been on it since February - after she had a small mast cell removal off of her hip. I feel that it has helped her heal faster and stay healthy. This will continue to be part of her daily diet. Thank you for making such a great supplement for our four-legged friends!

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    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Robin, Thank you so much for sharing your story! Lily is absolutely beautiful, and at 13 years old, it’s wonderful to hear how well she’s doing after her mast cell removal 🐾. We’re thrilled she’s a fan and feeling stronger and healthier—your love and care shine through in every step of her healing journey. 💛

    Reviewed by Debbie M.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Soft-Coated Wheaten Terrier
    Cat Breed
    Siberian
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Great for cats & dogs!

    Our Siberian cat died of a cancerous tumor last year. So I did research and found this product for our other cat and dog. I don't want either of them to get cancer. My husband & I love a mushroom supplement so giving them the pet version seemed right. I sprinkle it on their food every meal. They love it. The vet says both pets are extremely healthy. Both are over 10 yrs old.

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    Pet Wellness Direct

    Hi Debbie, thank you for sharing your story—your pets are absolutely beautiful, and we’re so sorry for your loss of your sweet Siberian cat 💛. It’s clear how deeply you care, and we’re thrilled to hear that both your senior cat and dog are thriving with Critical Immune Defense in their routine. Sprinkling it on each meal is such a great way to support their health, and we love that your vet sees the difference too.🐾

    Reviewed by Steven B.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Pitbull Terrier
    Pet Problem(s)
    • Tumor
    • Low Energy
    • Joint Pain
    • Inflammation
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    HAS HELPED IMMENSELY!

    About 2 months ago we found several lumps on our 11yo girl Diem. We lost our 9yo boy Bennett back in October and it was devastating. If only I had come across this back while he was still alive I feel like it could’ve made a considerable difference. Since she’s been on the critical immune defense no more lumps have formed and the ones she has have either not increased in size! Her energy levels have increased too. It has been such a relief to my wife and I knowing we will have more time with her. I would highly recommend this to anyone wanting to boost their pets immune system!

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    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Steven, thank you for sharing, and we're so sorry about Bennett. 💛 We’re thrilled to hear Diem is doing better—more energy and no new lumps is amazing news! 🐾 She looks so strong and loved. Wishing you many more happy moments together!