Critical Immune Defense

Sale price$65.00 USD
Size: 1 Bottle

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1530 reviews
    • 5 Stars
      1261 Reviews
    • 4 Stars
      157 Reviews
    • 3 Stars
      79 Reviews
    • 2 Stars
      9 Reviews
    • 1 Star
      24 Reviews
    93% of reviewers would recommend this product to a friend
    1530 Reviews
    Reviewed by Mary R.
    Verified Buyer
    Review posted
    Rated 3 out of 5

    No change detected

    It’s hard to review when you can’t measure how this product is helping our dog. She’s a rescue and has skin issues that have not improved. The only thing that’s showing any improvement is an oatmeal bath. Hair still hasn’t regrown but it appears to be helping with the scabbing. As to what maybe going on in her body, it’s hard to know.

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    Pet Wellness Direct

    Hi Mary, thank you for sharing your honest experience with your sweet rescue girl—she looks so lovable in her photo! 🐾💚 We know how challenging skin issues can be, especially when progress isn’t easy to measure. We're glad to hear the oatmeal baths are helping with her scabbing, and we hope that with time, her overall health continues to improve from the inside out. Please don’t hesitate to reach out—we’d love to support you both however we can!

    Reviewed by Jose T.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Trixie is doing great!

    About four months ago the vet gave me the bad news of Trixie having a 10 centimeter long growth next to her liver and risk of surgery would be very high. Additionally she had a growth on her side. Only three weeks after adding Critical Immune Defense to her diet we noticed a decrease of her growth and it now less than half the size. We don’t know yet if there has been a change with her internal tumor but we have noticed an increase of energy and we are back to doing 10,000 steps. Not bad for a 14 year old dog!

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    Pet Wellness Direct

    Hi Jose, thank you for sharing Trixie’s journey—she looks incredible for 14! 🐾💚 We’re so happy to hear her growth has shrunk and she’s full of energy again, hitting 10,000 steps like a pro. You’re doing an amazing job, and we’re honored to be part of her wellness routine!

    Reviewed by Paula T.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Great Product

    I started my GSD Joy on this a month ago.

    She loves the taste and I see a difference in her coat. Her fur was more coarse than normal and has softened. It also has a shine to it that it did not have before. So far, I love what it’s doing for her! I do believe that if they are healthy on the inside, it blooms on the outside!

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    Pet Wellness Direct

    Hi Paula, thank you so much for sharing Joy’s progress with us! 🐶💚 She looks absolutely radiant in her photo—her shiny, soft coat says it all. We’re so happy to hear she loves the taste and that you’re already seeing visible changes after just a month. Give Joy some extra belly rubs from us!

    Reviewed by Mary G.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Amazing support for senior dogs

    My oldest dog, now 15, had a rough year with difficult to diagnose coughing and wheezing. He was slowing down noticeably. His sister was pepper but lots of lumps and bumps. I don't normally try things I see online but this seemed worth a shot and I'm amazed. The coughing is under control, there's more pep in both pups, and I believe the lumps and bumps less noticeable. About to order more!

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    Pet Wellness Direct

    Hi Mary, thank you so much for sharing your heartfelt experience—we’re thrilled to hear how well your 15-year-old pup and his sister are doing! 🐾💚 Your video is just the sweetest, and it’s amazing to know the coughing has eased up and they’ve both regained some pep. Senior years can be tough, and your love and care clearly mean the world to them. We’re honored Critical Immune Defense is helping support their health and happiness!

    Reviewed by Virginia S.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    GREAT PRODUCT!

    Tango loves his Critical Immune Defense. Putting it on subscription - so I don't' forget!

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    Pet Wellness Direct

    Hi Virginia, thank you so much for the kind words! 🐶💚 Tango looks like such a happy, healthy pup in his photo, and it’s awesome that you’ve already seen enough of a difference to subscribe. We're so glad Critical Immune Defense is now a trusted part of his routine!