Critical Immune Defense

Rated 4.7 out of 5
Based on 1164 reviews
Sale price$65.00 USD
Size: 1 Bottle
Free shipping on subscriptions AND all orders over $75

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1164 reviews
    • 5 Stars
      964 Reviews
    • 4 Stars
      116 Reviews
    • 3 Stars
      57 Reviews
    • 2 Stars
      7 Reviews
    • 1 Star
      20 Reviews
    93% of reviewers would recommend this product to a friend
    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
    1164 Reviews
    Reviewed by Laura I.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Australian Shepherd
    Pet Problem(s)
    • Tumor
    Will Consume Product
    Enjoyed
    Pet Happiness
    Tail Wagging

    Amazing results

    I used this for two months and noticed a huge reduction in the lumps in my Aussie. Then we had budget cuts. I ordered from a different company and all his lumps came back. 😭

    So as expensive as this is, it does work incredibly well. I wish every dog that needed it could have it accessible.

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Laura, thank you for sharing your story about your Aussie; he is very handsome! 😍 It's so wonderful to hear about the huge progress he made with Critical Immune Defense, especially with his joint pain and inflammation. Your dedication shines through, and we hope he continues to feel great with it back in his routine!

    Reviewed by Carol O.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Poodle
    Pet Problem(s)
    • Inflammation
    • Limp
    Will Consume Product
    Enjoyed
    Pet Happiness
    Just Right

    Jojo

    I believe my pet had more energy after taking this product. Still limped tho

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    Effectiveness
    Rated 0 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Carol, thanks for sharing! It’s great to hear that Jojo is showing more energy after starting Critical Immune Defense, even with the limp. Hopefully, the product continues to help with inflammation and comfort. Please keep us updated.🐾

    Reviewed by Mary P.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    7 - 10 Years
    Dog Breed
    Golden Retriever
    Will Consume Product
    Devoured
    Pet Happiness
    Just Right

    Good stuff!

    My two dogs who are 9 years have been on Immune defense for at least a year and remain healthy , according to their vet visits every six months, tho I haven’t bothered to tell him that I use this. I sprinkle a scoop over their food every morning and they gobble up everything.

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    Effectiveness
    Rated 1 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Mary, thank you for sharing your experience! 🐾 It’s fantastic to hear that your 9-year-old Golden Retrievers are staying healthy with Critical Immune Defense. It sounds like they love their morning sprinkle—no wonder they’re thriving! Keep up the great work! They are adorable! 😊

    Reviewed by Juliet M.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    10+ Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Tumor
    • Cancer
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Critical immune defense

    My Morkie Blossom was diagnosed with melanoma cancer of the lip. We had it removed then we found immune defense and put her on it 1 month after surgery she is doing great.. the vet had told us 2 to 3 months if we did not do chemo or a new shot that cost 20000 dollars that would maybe give her 1 year with a possibility of side effects.. I’m excited to say it’s been 7 months and she is active playing ball every day. We did up the dosage after a lymph node in her neck has been swollen for a couple of months and added a probiotic to her diet…We are just so happy to have her for as long as we can and her feeling good and happy. I would highly recommend this product it gave our baby the best option in extending her life..

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    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Thank you, Juliet, for sharing Blossom's amazing journey! 🌸 We're so glad to hear she’s doing well and still playing ball daily—what a fighter! Your love and care are making a difference!🐾

    Reviewed by Anne J.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5
    Pet Age
    5 - 7 Years
    Dog Breed
    Mixed Breed
    Pet Problem(s)
    • Tumor
    • Cancer
    Will Consume Product
    Devoured
    Pet Happiness
    Tail Wagging

    Tumor control

    My dog has had two surgeries for MAST cell tumors, the first at age two and again this summer at age six. The margins for the second surgery were not clean and the recommendation was for radiation, followed by chemo, if more proved necessary. There's the cost and the side effects of radiation and chemo, which I did not want Sherlock to endure. I needed to find another route. There aren't many vets - beyond acupuncture and some chiropractic treatments - who provide alternative approaches. For my own health, I have been consuming mushroom powders since 2020 when I viewed Paul Stamets' documentary, Fantastic Fungi. I knew that is what I wanted for my dog. Foruntately, I could research information online - my vet had no ideas beyond the conventional ones - and found Pet Wellness Direct in that process. CID - the right ingredients in the right amounts with vet-researched understanding of which mushrooms will have the best results. Immediately after Sherlock's second surgery, two "faux nipples" appeared, oddly symmetrical, right across from each other. After one month of CID, those have receded. A dog park person told me something of value to us all, something my own vet did not tell me - it isn't wise to do the needle test on a lump suspected to be a MAST cell abberation; the cells go "berserk", spread, and then surgery is unavoidable. Since he'd just had a surgery - we were there to remove the staples when I pointed out the new growths - I said no to needle test before I knew of…

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    Effectiveness
    Rated 2 on a scale of minus 2 to 2, where minus 2 is Low, 0 is Medium and 2 is High
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    Pet Wellness Direct

    Hi Anne! Thank you for sharing Sherlock's journey with us. Hearing how Critical Immune Defense has helped him recover and stay energetic after his surgeries is wonderful. Sherlock's progress photos and his picture looks very handsome! You’ve made great decisions for his care, and we’re thrilled to be part of his health journey. Wishing you both continued success! 🐾💛