Critical Immune Defense

Sale price$65.00 USD
Size: 1 Bottle

Protect Your Pet from Life-Threatening Disease. A safe, all-natural immune booster that can add years to the life of your pet. Made in the USA.

✔︎  Boosts immune system
✔︎  Reduces inflammation
✔︎  Promotes normal cell growth
✔︎  Protects against toxins in food, water & environment
✔︎  Supports long-term health in dogs and cats

    Strengthens the Immune System

    Boosts the growth of "good" cells that fight disease and are essential for your pet’s long-term health.

    Promotes Normal Cell Growth

    Improves the immune system’s ability to monitor cell development and eliminate abnormalities.

    Can Extend Your Pet's Life

    Includes powerful antioxidants that reduce cellular aging and promote greater health & longevity.

    Protects Against Diseases

    Eliminates harmful pathogens such as bacteria and viruses that cause inflammation and infection.

    Works With Prescription Medications

    Great for pets on chemotherapy treatment, prescription steroids, pain medication & more.

    Backed By Science

    Asian cultures have used these all-natural ingredients to treat diseases and cancers for 1,000's of years.

    Critical Immune Defense is a powder that you sprinkle just a small amount on your dog or cat's food. It TASTES GREAT - even for the most finicky of pets.

    Key Ingredients

    Turkey Tail Mushroom

    This colorful mushroom has been used for centuries in Asia to treat disease and contains high levels of active compounds that have been proven to inhibit the growth of cancerous tumors.

    Reishi Mushroom

    This woody fungi is known as one of the top natural superfoods and has been used for 1000s of years to fight inflammation, cancer, heart disease, hormonal imbalances and more.

    Shiitake Mushroom

    According to the Journal of Nutrition, shiitake mushrooms provide antiviral, antibacterial and antifungal protection and help to control blood sugar and reduce inflammation.

    Maitake Mushroom

    Maitake mushrooms are loaded with vitamins and active ingredients that stimulate the immune system and promote natural hormone balance and healthy cell growth.

    White Turmeric Root Extract

    Turmeric has been used for centuries to reduce pain and inflammation. Its active ingredient, curcumin, has proven to be effective at blocking the growth of certain cancers and protecting against neurodegenerative diseases, arthritis, cardiovascular risks and
    liver damage.

    Ingredients & Usage Direction:

    (Approximately 70 Scoops Per Container)

    (Approximately 70 Scoops Per Container)

    Made In The USA To The Highest Quality Standards

    VetSmart Formulas is made in the USA in FDA audited facilities which adhere to cGMP and are audited by Underwriter Labs.

    Every ingredient is carefully inspected and tested before processing, ensuring a consistently safe, high-quality product for your beloved dog’s health.

    Your pet's immune system is the key to its health! Here's why:

    In today’s world, viruses and diseases are rampant, and it can be challenging to protect your pet.

    Let’s face it. Your pet lives in a world filled with contamination.

    They spend 90% of their waking hours on the floor, mopping up toxins, chemicals, and pollutants.

    The household cleaning products, fertilizer on the lawn, and preservatives in their foods can be harmful. Bacteria, airborne contaminants, and viruses transmitted by humans can challenge their health.

    Most pets do not eat an optimal diet, and likely do not get as much exercise as they require.

    What do you do?

    You need to put your pet’s immune system in overdrive!

    Research shows that a well-balanced and functional immune system is essential to your pet’s overall health and well-being.

    The doctors agree

    Mushrooms = Anticancer Activity

    “As a pet lover, I think it makes sense that the compounds in mushrooms be included in your pet’s diet or included by nutritional supplements. Certain mushrooms contain agents with anticancer activity and immunomodulatory properties that may help fight cancer and certain other diseases.”

    Dr. Frank Markland, Professor of biochemistry and molecular medicine at the University of Southern California Keck School of Medicine.

    Pet owners CAN make a difference.

    “It is the responsibility of the pet owner to do everything possible to minimize the risk of cancer in their pets. This includes a sensible lifestyle with sufficient exercise, weight management, drinking clean water, healthy food intake, and avoiding toxins. Giving your pets a high-quality antioxidant supplement is highly recommended to further reduce the risk of cancer.”

    – Dr. Shawn Messonnier, Veterinarian and Founder of Paws & Claws Animal Hospital in Plano, Texas.

    More cats and dogs are being diagnosed with cancer than ever before. 

    “Certain mushrooms and turmeric may be beneficial in helping your pet to boost its immune system to fight diseases,” explains Edwards.

    “Cancer is affecting our pets at alarming rates, and it is devastating for both the families of these pets as well as the pets themselves. I am seeing this in my practice on a regular basis.”

    Dr. Jennifer Edwards, Veterinarian at Ponemah Veterinary Hospital in Amherst, New Hampshire.

    No Artificial Colors

    No Artificial Flavors

    Wheat-free

    Frequently Asked Questions

    Verified Product Reviews

    average rating 4.7 out of 5
    Based on 1546 reviews
    • 5 Stars
      1275 Reviews
    • 4 Stars
      159 Reviews
    • 3 Stars
      79 Reviews
    • 2 Stars
      9 Reviews
    • 1 Star
      24 Reviews
    1546 Reviews
    Reviewed by Donna M.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Coopers cancer journey.

    My goldendoodle Cooper was diagnosed with anal gland cancer at 61/2 years old. He had surgery followed by 6 rounds of chemotherapy. When we stopped chemo , our vet has treated him with a steroid injection for about a year now. All of a sudden we saw Coopers health decline again. Vet took blood and chest X-ray and his cancer has spread. I started coopers on pet Defense about a month ago and I can see he feels better. We also started to feed him boiled chicken and vegetables once a day keeping carbs low. I don’t know how long Cooper will be with me but I want to make sure I am doing everything I can to keep him healthy and Pet Defense is working in front of my eyes.

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    Pet Wellness Direct

    Hi Donna, thank you for sharing Cooper’s journey. He looks so strong and sweet in his photo 💛🐾. We’re glad to hear that Critical Immune Defense is helping him feel better—your care, from chemo to a low-carb diet, is truly inspiring. Cooper is lucky to have you by his side, and we’re honored to be part of his journey.

    Reviewed by Barry D.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 4 out of 5

    So Far So Good

    Just started two weeks ago in en effort to reduce and/or eliminate lipomas. So far my dog tolerates it but doesn’t love it. My only complaint is based on the dog’s size and recommended treatment amount are not made clear in the product website. As a result, you start to runout before the month is up and the next bottle is received.

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    Pet Wellness Direct

    Hi Barry, thank you for the honest and thoughtful feedback. Your pup looks wonderful in the photo—such a sweet face and strong spirit 🐾💛. We’re glad to hear they’re tolerating the product well so far, especially as you’re working to reduce those lipomas. We completely understand the concern about dosage clarity and timing, and we appreciate you pointing that out—it’s something we’re actively working on improving. Your care and attention to your dog’s health really shines, and we’re hopeful you’ll continue to see positive changes ahead!

    Reviewed by Pamela S.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    Critical care immune powder

    My dogs have been on this for about 2 yrs give or take.It seems to help my 14 year with her energy and health,I give it to the 2 younger ones as a preventive care.I even sprinkle a little in my 21 yr old cats food, she’s pretty fussy so sometimes she’ll eat other times no.Sadly though we just lost our 10 yr old bulldog to a mass tumor on the side of her face.

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    Pet Wellness Direct

    Thank you, Pamela. We’re so sorry for the loss of your beloved bulldog—our hearts go out to you 💔🐾. It’s wonderful to hear that your 14-year-old pup is staying energized and that the younger ones (and even your picky 21-year-old cat!) are benefiting from the support. You’re giving them all so much love and care—thank you for sharing their story.

    Reviewed by Sue L.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    At 9 years young- she still has her ‘joie de vivre’

    Critical Immune Defense helps to keep our 9 year old Labradoodle full of energy and love to still she her friends

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    Pet Wellness Direct

    Thank you so much for sharing, and please give your sweet 9-year-old Labradoodle a big hug from us, too! 🐶 She looks absolutely radiant in her video—full of life, joy, and that unmistakable sparkle in her eyes. We’re thrilled to hear that Critical Immune Defense is helping her stay energetic and social, still loving her time with friends and embracing every day with her signature joie de vivre. Here’s to many more tail-wagging adventures ahead! 💚

    Reviewed by Patricia P.
    Verified Buyer
    Review posted
    I recommend this product
    Rated 5 out of 5

    I am ecstatic that this product is making a visible impact on HUGO!

    I have had a dog rescue for over 25 years and decided from the first dog we rescued that we were unable to rehome any of the dogs in our care. Over the years we have had up to 18 dogs in our care at any given time. Consequently we have lost many dogs to the feared C word and our personal cemetery and resting place is on the west side of our property. SMH. In walks HUGO, Nov 2024. A 120 lb mixed breed with the sweetest most docile personality. HUGO was last living with a senior woman who was and died from alcoholism and we learned that HUGO had never once been seen by a veterinarian. Hugo is roughly 12 years old. Just 1 month later I noticed a rather large and strange tumorish growth protruding out of his anus, at the same time I found a rather large hard lump in his left ear. Upon seeing our vet doctor he was confirmed to be riddled internally with the C- CANCER word and to our horror, Hugo was unable to have surgery because he had never been neutered ( that could be a death sentence). Our takeaway that day was: Doctors believe that he has perhaps a year left at best and I was absolutely crushed! So unfair to us and him. SMH!! Coincidentally I had just stumbled upon information about this product of yours: Critical Immune Defense. I dug deep and common sense told me that I should try this product on not just Hugo but also proactively for additional dogs in our home!!! For me? The product is rather pricey however it promised a better shot at saving Hugo than anything else I…

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    Pet Wellness Direct

    Hi Patti, thank you for sharing Hugo’s incredible journey. At 12 years old, he’s lucky to have found such a loving home after all he’s been through—and we adore his photo and video! Hearing that his ear lump is gone after 4 months on Critical Immune Defense is amazing news 🎉🐾. Your creativity in serving it (eggs, broth—so smart!) and your strength in the face of so many challenges is truly inspiring. We’re honored to be part of Hugo’s story and grateful for all the love you give your pups.